Comparison of 68 Ga-FAPI-04 and 18 F-FDG PET/CT in diagnosing ovarian cancer

This study assesses the diagnostic performance of Ga-FAPI-04 PET/CT compared to F-FDG PET/CT in primary, recurrent, and metastatic ovarian cancer. Seventy-nine ovarian cancer patients who performed Ga-FAPI-04 and F-FDG PET/CT were recruited. The target-to-background ratio (TBR), maximum standardized uptake value (SUV ), the number of positive lesions, visual assessment, the peritoneal cancer index (PCI) score, staging/restaging, and treatment strategies were compared from the corresponding PET/CT. Additionally, we analyzed and contrasted the diagnostic efficacy in both scans. Among all patients, 6 were assessed for initial assessment and 73 for recurrence and metastasis detection. For all lesions, Ga-FAPI-04 PET/CT demonstrated greater TBR than F-FDG PET/CT. Ga-FAPI-04 PET/CT demonstrated higher sensitivity for peritoneal metastases including patient-based and lesion-based analysis (95.00% vs. 83.33%, P = 0.065; 90.16% vs. 60.66%, P