TFEB/LAMP2 contributes to PM 0.2 -induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes

Atmospheric particulate matter (PM) exacerbates the risk factor for Alzheimer's and Parkinson's diseases (PD) by promoting the alpha-synuclein (α-syn) pathology in the brain. However, the molecular mechanisms of astrocytes involvement in α-syn pathology underlying the process remain unclea...

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Veröffentlicht in:	Journal of environmental sciences (China) 2024-11, Vol.145, p.117
Hauptverfasser:	Li, Ben, Liu, Ting, Shen, Yongmei, Qin, Jiangnan, Chang, Xiaohan, Wu, Meiqiong, Guo, Jianquan, Liu, Liangpo, Wei, Cailing, Lyu, Yi, Tian, Fengjie, Yin, Jinzhu, Wang, Tong, Zhang, Wenping, Qiu, Yulan
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - toxicity alpha-Synuclein - metabolism Animals Astrocytes - drug effects Autophagy - drug effects Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Lysosomal-Associated Membrane Protein 2 - metabolism Lysosomes - drug effects Lysosomes - metabolism Mice Mice, Inbred ICR Particulate Matter - toxicity
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Zusammenfassung:	Atmospheric particulate matter (PM) exacerbates the risk factor for Alzheimer's and Parkinson's diseases (PD) by promoting the alpha-synuclein (α-syn) pathology in the brain. However, the molecular mechanisms of astrocytes involvement in α-syn pathology underlying the process remain unclear. This study investigated PM with particle size
ISSN:	1001-0742
DOI:	10.1016/j.jes.2023.09.036