Drug concentrations in hair and dried blood spots as PrEP adherence metrics during pregnancy and postpartum

Drug concentrations in hair and dried blood spots as PrEP adherence metrics during pregnancy and postpartum

We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV pre-exposure prophylaxis (PrEP) during pregnancy and postpartum and compared hair levels with tenofovir-diphosphate (TFV-DP) levels in dried blood spots (DBS). Overall, 152 hair samples from 102 women and 36 hair-DBS pai...

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Veröffentlicht in:The Journal of infectious diseases 2024-05
Hauptverfasser: Wu, Linxuan, Kinuthia, John, Anderson, Peter L, Baeten, Jared M, Dettinger, Julia C, Gandhi, Monica, Gomez, Laurén, John-Stewart, Grace, Marwa, Mary M, Ngumbau, Nancy, Otieno, Felix, Omondi, Pascal, Odhiambo, Ben, Watoyi, Salphine, Pintye, Jillian
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Sprache:eng
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Zusammenfassung:We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV pre-exposure prophylaxis (PrEP) during pregnancy and postpartum and compared hair levels with tenofovir-diphosphate (TFV-DP) levels in dried blood spots (DBS). Overall, 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster randomized trial. Having a partner known to be living with HIV was associated with higher hair TFV levels (p
ISSN:1537-6613
DOI:10.1093/infdis/jiae208