Fluid-filled versus sensor-tipped pressure guidewires for FFR and P d /P a measurement; PW-COMPARE study
Fluid-filled pressure guidewires are unaffected by the previously inevitable hydrostatic pressure gradient (HPG). This study aimed to compare simultaneous pressure measurements with fluid-filled and sensor-tipped pressure guidewires. Fifty patients underwent fractional flow reserve (FFR) and P /P me...
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| Veröffentlicht in: | International journal of cardiology 2024-07, Vol.406, p.131998 |
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| container_start_page | 131998 |
| container_title | International journal of cardiology |
| container_volume | 406 |
| creator | Eerdekens, Rob Tonino, Pim A L Zimmermann, Frederik M Teeuwen, Koen Vlaar, Pieter-Jan de Waard, Guus A van Royen, Niels van Nunen, Lokien X |
| description | Fluid-filled pressure guidewires are unaffected by the previously inevitable hydrostatic pressure gradient (HPG). This study aimed to compare simultaneous pressure measurements with fluid-filled and sensor-tipped pressure guidewires.
Fifty patients underwent fractional flow reserve (FFR) and P
/P
measurement with a fluid-filled and a sensor-tipped pressure guidewire simultaneously. To assess maneuverability, patients were randomized with respect to which pressure guidewire was used to cross the lesion first. Lateral fluoroscopy was used to estimate height difference between catheter tip and distal wire position (and thus HPG). Agreement between pressure measurements was studied.
Measurements were performed in LM (4% (n = 2)), LAD (44% (n = 22)), LCX (26% (n = 13)), and RCA (26% (n = 13)). Simultaneous pressure measurements showed excellent agreement (mean FFR difference - 0.01 ± 0.03 (r = 0.959, p |
| doi_str_mv | 10.1016/j.ijcard.2024.131998 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_38555057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>38555057</sourcerecordid><originalsourceid>FETCH-pubmed_primary_385550573</originalsourceid><addsrcrecordid>eNqFjsFqwkAURQehqFX_oMj7gYkzJtNEuipi6EYMIriU0XnRCUkc5mVa_Pum0K67utx7zuIy9iJFJIV8XVSRrS7am2gplkkkY7laZQM2llmacJmqZMSeiSohRNKDIRvFmVJKqHTMbnkdrOGlrWs08ImeAgFhS3fPO-tcPzqPRMEjXHsTv2xfobx7yPM96NZAAQYWBWhoUP94DbbdGxRHvt5ti_f9BqgL5jFlT6WuCWe_OWHzfHNYf3AXzg2ak_O20f5x-rsW_yt8A3vrSp8</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Fluid-filled versus sensor-tipped pressure guidewires for FFR and P d /P a measurement; PW-COMPARE study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Eerdekens, Rob ; Tonino, Pim A L ; Zimmermann, Frederik M ; Teeuwen, Koen ; Vlaar, Pieter-Jan ; de Waard, Guus A ; van Royen, Niels ; van Nunen, Lokien X</creator><creatorcontrib>Eerdekens, Rob ; Tonino, Pim A L ; Zimmermann, Frederik M ; Teeuwen, Koen ; Vlaar, Pieter-Jan ; de Waard, Guus A ; van Royen, Niels ; van Nunen, Lokien X</creatorcontrib><description>Fluid-filled pressure guidewires are unaffected by the previously inevitable hydrostatic pressure gradient (HPG). This study aimed to compare simultaneous pressure measurements with fluid-filled and sensor-tipped pressure guidewires.
Fifty patients underwent fractional flow reserve (FFR) and P
/P
measurement with a fluid-filled and a sensor-tipped pressure guidewire simultaneously. To assess maneuverability, patients were randomized with respect to which pressure guidewire was used to cross the lesion first. Lateral fluoroscopy was used to estimate height difference between catheter tip and distal wire position (and thus HPG). Agreement between pressure measurements was studied.
Measurements were performed in LM (4% (n = 2)), LAD (44% (n = 22)), LCX (26% (n = 13)), and RCA (26% (n = 13)). Simultaneous pressure measurements showed excellent agreement (mean FFR difference - 0.01 ± 0.03 (r = 0.959, p < 0.001), mean P
/P
difference - 0.01 ± 0.04 (r = 0.929, p < 0.001)). FFR was ≤0.80 in 42.6% (n = 20) with fluid-filled FFR measurements versus 46.8% (n = 22) by sensor-tipped FFR measurements. Mean height difference was 15 ± 34 mm, and strongly dependent on the coronary artery (LAD 45 ± 10 mm, LCX -23 ± 16 mm, RCA -13 ± 17 mm). There was a strong correlation between height difference and difference in pressure ratios between sensor-tipped and fluid-filled pressure guidewires (FFR r = -0.850, p < 0.001; P
/P
r = -0.641, p < 0.001). Largest FFR differences were present in the LAD (-0.04 ± 0.02). After HPG correction, mean difference between HPG-corrected sensor-tipped FFR and fluid-filled FFR was 0.00 ± 0.02, mean P
/P
difference was 0.01 ± 0.03.
This study shows excellent overall correlation between FFR and P
/P
measurements with both pressure guidewires. Differences measured with fluid-filled and sensor-tipped pressure guidewires are vessel-specific and attributable to hydrostatic pressure gradients (NCT04802681).</description><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2024.131998</identifier><identifier>PMID: 38555057</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Aged ; Cardiac Catheterization - instrumentation ; Cardiac Catheterization - methods ; Coronary Angiography - methods ; Equipment Design ; Female ; Fractional Flow Reserve, Myocardial - physiology ; Humans ; Male ; Middle Aged ; Prospective Studies</subject><ispartof>International journal of cardiology, 2024-07, Vol.406, p.131998</ispartof><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38555057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eerdekens, Rob</creatorcontrib><creatorcontrib>Tonino, Pim A L</creatorcontrib><creatorcontrib>Zimmermann, Frederik M</creatorcontrib><creatorcontrib>Teeuwen, Koen</creatorcontrib><creatorcontrib>Vlaar, Pieter-Jan</creatorcontrib><creatorcontrib>de Waard, Guus A</creatorcontrib><creatorcontrib>van Royen, Niels</creatorcontrib><creatorcontrib>van Nunen, Lokien X</creatorcontrib><title>Fluid-filled versus sensor-tipped pressure guidewires for FFR and P d /P a measurement; PW-COMPARE study</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Fluid-filled pressure guidewires are unaffected by the previously inevitable hydrostatic pressure gradient (HPG). This study aimed to compare simultaneous pressure measurements with fluid-filled and sensor-tipped pressure guidewires.
Fifty patients underwent fractional flow reserve (FFR) and P
/P
measurement with a fluid-filled and a sensor-tipped pressure guidewire simultaneously. To assess maneuverability, patients were randomized with respect to which pressure guidewire was used to cross the lesion first. Lateral fluoroscopy was used to estimate height difference between catheter tip and distal wire position (and thus HPG). Agreement between pressure measurements was studied.
Measurements were performed in LM (4% (n = 2)), LAD (44% (n = 22)), LCX (26% (n = 13)), and RCA (26% (n = 13)). Simultaneous pressure measurements showed excellent agreement (mean FFR difference - 0.01 ± 0.03 (r = 0.959, p < 0.001), mean P
/P
difference - 0.01 ± 0.04 (r = 0.929, p < 0.001)). FFR was ≤0.80 in 42.6% (n = 20) with fluid-filled FFR measurements versus 46.8% (n = 22) by sensor-tipped FFR measurements. Mean height difference was 15 ± 34 mm, and strongly dependent on the coronary artery (LAD 45 ± 10 mm, LCX -23 ± 16 mm, RCA -13 ± 17 mm). There was a strong correlation between height difference and difference in pressure ratios between sensor-tipped and fluid-filled pressure guidewires (FFR r = -0.850, p < 0.001; P
/P
r = -0.641, p < 0.001). Largest FFR differences were present in the LAD (-0.04 ± 0.02). After HPG correction, mean difference between HPG-corrected sensor-tipped FFR and fluid-filled FFR was 0.00 ± 0.02, mean P
/P
difference was 0.01 ± 0.03.
This study shows excellent overall correlation between FFR and P
/P
measurements with both pressure guidewires. Differences measured with fluid-filled and sensor-tipped pressure guidewires are vessel-specific and attributable to hydrostatic pressure gradients (NCT04802681).</description><subject>Aged</subject><subject>Cardiac Catheterization - instrumentation</subject><subject>Cardiac Catheterization - methods</subject><subject>Coronary Angiography - methods</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Fractional Flow Reserve, Myocardial - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjsFqwkAURQehqFX_oMj7gYkzJtNEuipi6EYMIriU0XnRCUkc5mVa_Pum0K67utx7zuIy9iJFJIV8XVSRrS7am2gplkkkY7laZQM2llmacJmqZMSeiSohRNKDIRvFmVJKqHTMbnkdrOGlrWs08ImeAgFhS3fPO-tcPzqPRMEjXHsTv2xfobx7yPM96NZAAQYWBWhoUP94DbbdGxRHvt5ti_f9BqgL5jFlT6WuCWe_OWHzfHNYf3AXzg2ak_O20f5x-rsW_yt8A3vrSp8</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Eerdekens, Rob</creator><creator>Tonino, Pim A L</creator><creator>Zimmermann, Frederik M</creator><creator>Teeuwen, Koen</creator><creator>Vlaar, Pieter-Jan</creator><creator>de Waard, Guus A</creator><creator>van Royen, Niels</creator><creator>van Nunen, Lokien X</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20240701</creationdate><title>Fluid-filled versus sensor-tipped pressure guidewires for FFR and P d /P a measurement; PW-COMPARE study</title><author>Eerdekens, Rob ; Tonino, Pim A L ; Zimmermann, Frederik M ; Teeuwen, Koen ; Vlaar, Pieter-Jan ; de Waard, Guus A ; van Royen, Niels ; van Nunen, Lokien X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_385550573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Cardiac Catheterization - instrumentation</topic><topic>Cardiac Catheterization - methods</topic><topic>Coronary Angiography - methods</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Fractional Flow Reserve, Myocardial - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eerdekens, Rob</creatorcontrib><creatorcontrib>Tonino, Pim A L</creatorcontrib><creatorcontrib>Zimmermann, Frederik M</creatorcontrib><creatorcontrib>Teeuwen, Koen</creatorcontrib><creatorcontrib>Vlaar, Pieter-Jan</creatorcontrib><creatorcontrib>de Waard, Guus A</creatorcontrib><creatorcontrib>van Royen, Niels</creatorcontrib><creatorcontrib>van Nunen, Lokien X</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eerdekens, Rob</au><au>Tonino, Pim A L</au><au>Zimmermann, Frederik M</au><au>Teeuwen, Koen</au><au>Vlaar, Pieter-Jan</au><au>de Waard, Guus A</au><au>van Royen, Niels</au><au>van Nunen, Lokien X</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluid-filled versus sensor-tipped pressure guidewires for FFR and P d /P a measurement; PW-COMPARE study</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>406</volume><spage>131998</spage><pages>131998-</pages><eissn>1874-1754</eissn><abstract>Fluid-filled pressure guidewires are unaffected by the previously inevitable hydrostatic pressure gradient (HPG). This study aimed to compare simultaneous pressure measurements with fluid-filled and sensor-tipped pressure guidewires.
Fifty patients underwent fractional flow reserve (FFR) and P
/P
measurement with a fluid-filled and a sensor-tipped pressure guidewire simultaneously. To assess maneuverability, patients were randomized with respect to which pressure guidewire was used to cross the lesion first. Lateral fluoroscopy was used to estimate height difference between catheter tip and distal wire position (and thus HPG). Agreement between pressure measurements was studied.
Measurements were performed in LM (4% (n = 2)), LAD (44% (n = 22)), LCX (26% (n = 13)), and RCA (26% (n = 13)). Simultaneous pressure measurements showed excellent agreement (mean FFR difference - 0.01 ± 0.03 (r = 0.959, p < 0.001), mean P
/P
difference - 0.01 ± 0.04 (r = 0.929, p < 0.001)). FFR was ≤0.80 in 42.6% (n = 20) with fluid-filled FFR measurements versus 46.8% (n = 22) by sensor-tipped FFR measurements. Mean height difference was 15 ± 34 mm, and strongly dependent on the coronary artery (LAD 45 ± 10 mm, LCX -23 ± 16 mm, RCA -13 ± 17 mm). There was a strong correlation between height difference and difference in pressure ratios between sensor-tipped and fluid-filled pressure guidewires (FFR r = -0.850, p < 0.001; P
/P
r = -0.641, p < 0.001). Largest FFR differences were present in the LAD (-0.04 ± 0.02). After HPG correction, mean difference between HPG-corrected sensor-tipped FFR and fluid-filled FFR was 0.00 ± 0.02, mean P
/P
difference was 0.01 ± 0.03.
This study shows excellent overall correlation between FFR and P
/P
measurements with both pressure guidewires. Differences measured with fluid-filled and sensor-tipped pressure guidewires are vessel-specific and attributable to hydrostatic pressure gradients (NCT04802681).</abstract><cop>Netherlands</cop><pmid>38555057</pmid><doi>10.1016/j.ijcard.2024.131998</doi></addata></record> |
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| ispartof | International journal of cardiology, 2024-07, Vol.406, p.131998 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Cardiac Catheterization - instrumentation Cardiac Catheterization - methods Coronary Angiography - methods Equipment Design Female Fractional Flow Reserve, Myocardial - physiology Humans Male Middle Aged Prospective Studies |
| title | Fluid-filled versus sensor-tipped pressure guidewires for FFR and P d /P a measurement; PW-COMPARE study |
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