Comparison of different methods of first‐trimester screening for preterm pre‐eclampsia: cohort study

ABSTRACT Objective To compare the predictive performance of three different mathematical models for first‐trimester screening of pre‐eclampsia (PE), which combine maternal risk factors with mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI) and serum placental growth factor (PlG...

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Veröffentlicht in:	Ultrasound in obstetrics & gynecology 2024-07, Vol.64 (1), p.57-64
Hauptverfasser:	Cuenca‐Gómez, D., De Paco Matallana, C., Rolle, V., Mendoza, M., Valiño, N., Revello, R., Adiego, B., Casanova, M. C., Molina, F. S., Delgado, J. L., Wright, A., Figueras, F., Nicolaides, K. H., Santacruz, B., Gil, M. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult algorithm Algorithms Arterial Pressure biomarker Biomarkers - blood Blood pressure calibration Cohort analysis competing‐risks model Criteria Eclampsia Female Fetal Medicine Foundation Fetuses first trimester Gestation Gestational Age Growth factors Gynecology Humans Mathematical models Models, Theoretical Obstetrics Performance prediction Placenta growth factor Placenta Growth Factor - blood Population studies Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Predictive Value of Tests Preeclampsia Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A - analysis Pregnancy-Associated Plasma Protein-A - metabolism Prenatal Diagnosis - methods pre‐eclampsia Prospective Studies Pulsatile Flow Regression models Risk Assessment - methods Risk Factors risk scoring ROC Curve screening Spain Ultrasonic imaging Ultrasonography, Prenatal - methods Ultrasound Uterine Artery - diagnostic imaging validation
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Zusammenfassung:	ABSTRACT Objective To compare the predictive performance of three different mathematical models for first‐trimester screening of pre‐eclampsia (PE), which combine maternal risk factors with mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI) and serum placental growth factor (PlGF), and two risk‐scoring systems. Methods This was a prospective cohort study performed in eight fetal medicine units in five different regions of Spain between September 2017 and December 2019. All pregnant women with singleton pregnancy and a non‐malformed live fetus attending their routine ultrasound examination at 11 + 0 to 13 + 6 weeks' gestation were invited to participate in the study. Maternal characteristics and medical history were recorded and measurements of MAP, UtA‐PI, serum PlGF and pregnancy‐associated plasma protein‐A (PAPP‐A) were converted into multiples of the median (MoM). Risks for term PE, preterm PE (
ISSN:	0960-7692 1469-0705 1469-0705
DOI:	10.1002/uog.27622