Synthesis of imidazole-fused nitrogen-bridgehead heterocycles catalysed by lipase and their antifungal and antimicrobial bioactivity

An effective approach for selective C-N bond formation for synthesising imidazo[1,2- a ] pyridine-based heterocycles using porcine pancreatic lipase (PPL) as a biocatalyst has been devised. Under moderate conditions, a series of imidazo[1,2- a ]pyridine-based heterocycle derivatives were synthesised...

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Veröffentlicht in:RSC advances 2024-02, Vol.14 (8), p.537-544
Hauptverfasser: Singh, Manjit, Malviya, Manisha, Yadav, Vijay B, Nikhil, Aishwarya, Gupta, Munesh
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Sprache:eng
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Zusammenfassung:An effective approach for selective C-N bond formation for synthesising imidazo[1,2- a ] pyridine-based heterocycles using porcine pancreatic lipase (PPL) as a biocatalyst has been devised. Under moderate conditions, a series of imidazo[1,2- a ]pyridine-based heterocycle derivatives were synthesised with remarkable selectivity in good-to-excellent yields (89-95%). Further, the antimicrobial and antifungal activities of derivatives 3ha , 3ka , 3fa , 3hc , and 3eb were observed, and they were found to be biologically active in antimicrobial susceptibility tests for Gram-positive bacteria ( Enterococcus faecalis ATCC 29212 and Staphylococcus auris ATCC 25923 ), Gram-negative bacteria ( Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 ) and fungal strains ( Candida albicans ATCC 90028 and Candida tropicalis ATCC 750 ). An effective approach for selective C-N bond formation for synthesising imidazo[1,2- a ] pyridine-based heterocycles using porcine pancreatic lipase (PPL) as a biocatalyst has been devised.
ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra07145f