White Blood Cell Counts and Future Relapse in Ulcerative Colitis under Low-Dose Thiopurine Treatment in Real-World Practice: A 3-Year Japanese Multi-Center Retrospective Cohort Study

Abstract Introduction: Whether white blood cell (WBC) counts are predictors for the effectiveness of thiopurine treatment in ulcerative colitis (UC) has been inconclusive in previous studies with small sample sizes. We investigated the association between WBC counts and future relapses in UC patient...

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Veröffentlicht in:	Inflammatory intestinal diseases 2024-01, Vol.9 (1), p.1-10
Hauptverfasser:	Kiyohara, Hiroki, Yamazaki, Hajime, Moriya, Kei, Akimoto, Naohiko, Kawai, Shoichiro, Takenaka, Kento, Fukuda, Tomohiro, Tominaga, Keiichi, Umeno, Junji, Shinzaki, Shinichiro, Honzawa, Yusuke, Takagi, Tomohisa, Ichikawa, Hitoshi, Endo, Toshiyuki, Ozaki, Ryo, Andoh, Akira, Matsuoka, Katsuyoshi, Hibi, Toshifumi, Kobayashi, Taku
Format:	Artikel
Sprache:	eng
Schlagworte:	immunomodulator inflammatory bowel disease leukocyte maintenance therapy remission Research Article ulcerative colitis
Online-Zugang:	Volltext
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Zusammenfassung:	Abstract Introduction: Whether white blood cell (WBC) counts are predictors for the effectiveness of thiopurine treatment in ulcerative colitis (UC) has been inconclusive in previous studies with small sample sizes. We investigated the association between WBC counts and future relapses in UC patients in a large-scale multi-center study. Methods: This retrospective cohort study enrolled a total of 723 UC patients in remission from 33 hospitals and followed up for 3 years. Relapse was defined as a need for treatment intensification. The risk of relapse was compared among patients with the baseline WBC counts
ISSN:	2296-9403 2296-9365 2296-9365
DOI:	10.1159/000535889