Efficient Stereo-Selective Fluorination on Vitamin D 3 Side-Chain Using Electrophilic Fluorination

Efficient Stereo-Selective Fluorination on Vitamin D 3 Side-Chain Using Electrophilic Fluorination

Our research regarding side-chain fluorinated vitamin D analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D side-chain was developed using -fluorobenzenesulfonimide (...

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Veröffentlicht in:Biomolecules (Basel, Switzerland) Switzerland), 2023-12, Vol.14 (1)
Hauptverfasser: Kawagoe, Fumihiro, Mototani, Sayuri, Kittaka, Atsushi
Format: Artikel
Sprache:eng
Schlagworte:
Cholecalciferol
Halogenation
Imides
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Zusammenfassung:Our research regarding side-chain fluorinated vitamin D analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D side-chain was developed using -fluorobenzenesulfonimide (NFSI) and CD-ring imides with an Evans chiral auxiliary ( , , ).
ISSN:2218-273X
DOI:10.3390/biom14010037