Neonatal administration of 5,7-dihydroxytryptamine induces in the adult rat a decrease in paradoxical sleep restored by an intracisternal injection of fetal raphe cells

By a method of automatic on-line scoring of sleep-waking stages in the rat, a significant decrease of the mean circadian level of paradoxical sleep and a significant increase of light slow sleep were shown in adult animals after neonatal disruption of serotoninergic system by intracisternal injectio...

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Veröffentlicht in:	Revue d'électroencéphalographie et de neurophysiologie clinique 1986-10, Vol.16 (3), p.273
Hauptverfasser:	Glin, L, Gandolfo, G, McRae Degueurce, A, Gottesmann, C
Format:	Artikel
Sprache:	fre
Schlagworte:	5,7-Dihydroxytryptamine - pharmacology Animals Fetus Male Raphe Nuclei - physiology Raphe Nuclei - transplantation Rats Rats, Inbred Strains Serotonin - physiology Sleep, REM - drug effects Sleep, REM - physiology
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Zusammenfassung:	By a method of automatic on-line scoring of sleep-waking stages in the rat, a significant decrease of the mean circadian level of paradoxical sleep and a significant increase of light slow sleep were shown in adult animals after neonatal disruption of serotoninergic system by intracisternal injection of 100 micrograms of 5.7-dihydroxytryptamine, when compared to an aged matched sham group. The level of paradoxical sleep was restored in the neurotoxin-treated rats by an intracisternal injection of a suspension of foetal raphe neurons.
ISSN:	0370-4475