Water Vapor Thermal Therapy in Men With Prostate Volume ≥80 cm 3 : A Systematic Review and Meta-Analysis

To determine the safety and effectiveness of water vapor thermal therapy (Rezum) in men with large prostate volumes of at least 80cm . We performed systematic searches for studies of Rezum therapy in men with prostate volume of at least 80 cm . Meta-analysis outcomes included the International Prostate Symptom Score (IPSS), IPSS Quality of Life (IPSS-QOL), Qmax, postvoid residual, International Index of Erectile Function-Erectile Function (IIEF-EF), and serious (Clavien-Dindo grade III-V) complications, surgical retreatments. Outcomes were analyzed using a random effects meta-analysis model. The review included 15 studies (11 retrospective) of 471 men with prostate volume at least 80 cm treated with Rezum therapy and followed for a median of 6months (range: 3-17months). Rezum therapy resulted in statistically significant improvements in IPSS (mean change: -11.0; 95% CI: -12.2, -9.7; P