13 C and 15 N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue
Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of C, N assi...
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| Veröffentlicht in: | Biomolecular NMR assignments 2023-12, Vol.17 (2), p.281 |
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| container_title | Biomolecular NMR assignments |
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| creator | Barclay, Alexander M Dhavale, Dhruva D Borcik, Collin G Milchberg, Moses H Kotzbauer, Paul T Rienstra, Chad M |
| description | Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of
C,
N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia. |
| format | Article |
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C,
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| fulltext | fulltext |
| identifier | EISSN: 1874-270X |
| ispartof | Biomolecular NMR assignments, 2023-12, Vol.17 (2), p.281 |
| issn | 1874-270X |
| language | eng |
| recordid | cdi_pubmed_primary_37919529 |
| source | MEDLINE; SpringerNature Journals |
| subjects | alpha-Synuclein - chemistry Humans Lewy Body Disease - pathology Multiple System Atrophy - metabolism Multiple System Atrophy - pathology Nuclear Magnetic Resonance, Biomolecular Parkinson Disease - metabolism Parkinson Disease - pathology |
| title | 13 C and 15 N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue |
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