13 C and 15 N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue

Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of C, N assi...

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Veröffentlicht in:	Biomolecular NMR assignments 2023-12, Vol.17 (2), p.281
Hauptverfasser:	Barclay, Alexander M, Dhavale, Dhruva D, Borcik, Collin G, Milchberg, Moses H, Kotzbauer, Paul T, Rienstra, Chad M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry Humans Lewy Body Disease - pathology Multiple System Atrophy - metabolism Multiple System Atrophy - pathology Nuclear Magnetic Resonance, Biomolecular Parkinson Disease - metabolism Parkinson Disease - pathology
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Zusammenfassung:	Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of C, N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.
ISSN:	1874-270X