Caveolae-associated cAMP/Ca 2+ -mediated mechano-chemical signal transduction in mouse atrial myocytes

Caveolae are tiny invaginations in the sarcolemma that buffer extra membrane and contribute to mechanical regulation of cellular function. While the role of caveolae in membrane mechanosensation has been studied predominantly in non-cardiomyocyte cells, caveolae contribution to cardiac mechanotransd...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2023-11, Vol.184, p.75
Hauptverfasser:	Medvedev, Roman Y, Turner, Daniel G P, DeGuire, Frank C, Leonov, Vladislav, Lang, Di, Gorelik, Julia, Alvarado, Francisco J, Bondarenko, Vladimir E, Glukhov, Alexey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Fibrillation - metabolism Caveolae - metabolism Cyclic AMP - metabolism Mechanotransduction, Cellular Mice Myocytes, Cardiac - metabolism Signal Transduction - physiology
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Zusammenfassung:	Caveolae are tiny invaginations in the sarcolemma that buffer extra membrane and contribute to mechanical regulation of cellular function. While the role of caveolae in membrane mechanosensation has been studied predominantly in non-cardiomyocyte cells, caveolae contribution to cardiac mechanotransduction remains elusive. Here, we studied the role of caveolae in the regulation of Ca signaling in atrial cardiomyocytes. In Langendorff-perfused mouse hearts, atrial pressure/volume overload stretched atrial myocytes and decreased caveolae density. In isolated cells, caveolae were disrupted through hypotonic challenge that induced a temporal (
ISSN:	1095-8584
DOI:	10.1016/j.yjmcc.2023.10.004