Chemical reaction networks based on conjugate additions on β′-substituted Michael acceptors

Over the last few decades, the study of more complex, chemical systems closer to those found in nature, and the interactions within those systems, has grown immensely. Despite great efforts, the need for new, versatile, and robust chemistry to apply in CRNs remains. In this Feature Article, we give a brief overview over previous developments in the field of systems chemistry and how β′-substituted Michael acceptors (MAs) can be a great addition to the systems chemist's toolbox. We illustrate their versatility by showcasing a range of examples of applying β′-substituted MAs in CRNs, both as chemical signals and as substrates, to open up the path to many applications ranging from responsive materials, to pathway control in CRNs, drug delivery, analyte detection, and beyond. The diverse reactivity of β′-substituted Michael acceptors make them a perfect fit for the application in Chemical Reaction Networks (CRNs). We show how these CRNs can find use in material science, signal amplification, and beyond.