From Nose to Lumbar Spinal Cord; Reduced Sperm Numbers occur by Olfactory Bulbectomy-releted Onuf's Nucleus Degeneration; New Experimental Evidence for Kallmann Syndrome

Olfaction and its relation to human health is an area of growing interest. Although olfaction disorders have been considered a part of Kallmann Syndrome, the role of olfactory dysfunction on spermatogenesis has not been studied yet. We studied if olfactory bulbectomy causes dysfunction in spermatogenesis as a result of Onuf's nucleus damage. Twenty-eight male rats were divided into three groups: six as the control (G-1; n=6), six as the only frontal burr-hole applied animals SHAM (G-1I; n=6), and 16 as the study group (G-III; n=16) in which OBX was performed. The animals were followed for two months. After the decapitation of the animals, olfactory bulb (OB) volumes (mm3), the neuron density of the Onuf nucleus (n/mm3), and sperm density (n/mm3) were estimated stereologically, and analyzed. Olfactory bulb volumes (mm3), degenerated neuron density of Onuf's nucleus (n/mm3), and sperm numbers of control, SHAM, and study groups were estimated as: 4±0.5; 6±2 and 103.245±10.841 in G-I; 3.5±0.7; 14±4 and 96.891±9.569 in G-II and 1.3±0.3; 91±17 and 73.561±6.324 in GIII. The statistical results of degenerated neuron density of Onuf's nucleus and sperm numbers between groups are as p