Value for combination of T 1 WI star - VIBE with TWIST - VIBE dynamic contrast - enhanced MRI in distinguishing lung nodules

With the increasing detection rate of lung nodules, the qualitative problem of lung nodules has become one of the key clinical issues. This study aims to evaluate the value of combining dynamic contrast-enhanced (DCE) MRI based on time-resolved imaging with interleaved stochastic trajectories-volume interpolated breath hold examination (TWIST-VIBE) with T weighted free-breathing star-volumetric interpolated breath hold examination (T WI star-VIBE) in identifying benign and malignant lung nodules. We retrospectively analyzed 79 adults with undetermined lung nodules before the operation. All nodules of patients included were classified into malignant nodules ( =58) and benign nodules ( =26) based on final diagnosis. The unenhanced T WI-VIBE, the contrast-enhanced T WI star-VIBE, and the DCE curve based on TWIST-VIBE were performed. The corresponding qualitative [wash-in time, wash-out time, time to peak (TTP), arrival time (AT), positive enhancement integral (PEI)] and quantitative parameters [volume transfer constant (Ktrans), interstitium-to-plasma rate constant (Kep), and fractional extracellular space volume (Ve)] were evaluated. Besides, the diagnostic efficacy (sensitivity and specificity) of enhanced CT and MRI were compared. There were significant differences in unenhanced T WI-VIBE hypo-intensity, and type of A, B, C DCE curve type between benign and malignant lung nodules (all 0.05). After T WI star-VIBE contrast-enhanced MRI, the image quality was further improved. Compared with enhanced CT scan, the sensitivity (82.76% vs 80.50%) and the specificity (69.23% vs 57.10%) based on MRI were higher than that of CT (both