TOXICOLOGICAL STUDIES ON (2R)-4'-O-TETRAHYDROPYRANYLADRIAMYCIN, A NEW ANTITUMOR ANTIBIOTIC: ITS SUBACUTE TOXICITY IN MALE BEAGLE DOGS

In the previous paper1) on the subacute toxicity and recovery study of (2R)-4'-O-tetrahydropyranyladriamycin (THP), a new antitumor antibiotic in Beagle dogs, it has been suggested that the maximum non-toxic dose is less than 0.01mg/kg/day to males, because this compound has caused some damages on the testes even at the lowest dose of 0.01mg/kg/day. Therefore, the objective of this study is furthermore to examine 13-week subacute toxicity of THP in male Beagle dogs at low doses of 0.0001, 0.001 and 0.01mg/kg/day to determine the level of nontoxic dose.