ZnO-NPs alleviate aflatoxin B 1 -induced hepatoxicity in ducklings by promoting hepatic metallothionein expression

Aflatoxin B (AFB ) is a mycotoxin widely present in animal feed and human food, posing a serious threat to animal and human health. This study was aim to illustrate the mechanism of the protective role of MT against AFB -induced hepatotoxicity, as well as to explore the feasibility of enhancing the...

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Veröffentlicht in:	Ecotoxicology and environmental safety 2023-05, Vol.256, p.114826
Hauptverfasser:	Zhang, Beiyu, Li, Meiling, Zhou, Guangteng, Gu, Xin, Xie, Longqiang, Zhao, Man, Xu, Qingbiao, Tan, Gaoming, Zhang, Niya
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 - toxicity Animals Antioxidants - metabolism Drug-Related Side Effects and Adverse Reactions - metabolism Ducks - metabolism Humans Liver NF-E2-Related Factor 2 - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Superoxide Dismutase - metabolism Zinc Oxide - metabolism
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Beschreibung
Zusammenfassung:	Aflatoxin B (AFB ) is a mycotoxin widely present in animal feed and human food, posing a serious threat to animal and human health. This study was aim to illustrate the mechanism of the protective role of MT against AFB -induced hepatotoxicity, as well as to explore the feasibility of enhancing the tolerance of poultry to AFB by upregulating the expression of hepatic MT. After being exposed to AFB (50 ng/kg) primary duckling hepatocytes, the cell viability, the antioxidant index (SOD and GPx) and the mRNA levels of MT downstream genes (PTGR, p53, TrxR, AR and Bcl-2) significantly (p
ISSN:	1090-2414