Improved mineralization of dental enamel by electrokinetic delivery of F - and Ca 2+ ions
This in vitro study evaluated the effects of the infiltration of F and Ca ions into human enamel by electrokinetic flow (EKF) on the enamel microhardness and F content. Sound human enamel ground sections of unerupted third molars were infiltrated with de-ionized water by EKF and with F ion by EKF re...
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| Veröffentlicht in: | Scientific reports 2023-01, Vol.13 (1), p.516 |
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| creator | Tay, NamBeng Gan, HiongYap de Sousa, Frederico Barbosa Shen, Lu Nóbrega, Diego Figueiredo Peng, Chenhui Kilpatrick-Liverman, LaTonya Wang, Wei Lavender, Stacey Pilch, Shira Han, Jongyoon |
| description | This in vitro study evaluated the effects of the infiltration of F
and Ca
ions into human enamel by electrokinetic flow (EKF) on the enamel microhardness and F
content. Sound human enamel ground sections of unerupted third molars were infiltrated with de-ionized water by EKF and with F
ion by EKF respectively. All samples were submitted to two successive transverse acid-etch biopsies (etching times of 30 s and 20 min) to quantify F
ion infiltrated deep into enamel. Remarkably, sound enamel showed a large increase in microhardness (MH) after infiltration of NaF (p |
| doi_str_mv | 10.1038/s41598-022-26423-4 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_36627315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>36627315</sourcerecordid><originalsourceid>FETCH-pubmed_primary_366273153</originalsourceid><addsrcrecordid>eNqFjjGrwjAUhYMgKk__gIPcXfJMbtJqZ1F0d3GSaK8QTdKS9Al9v94KOnuWbzgfh8PYVIpfKdRqkbTMihUXiBxzjYrrHhuh0BlHhThkk5RuokuGhZbFgA1VnuNSyWzEjntfx-pBJXgbKBpn_01jqwDVFUoKjXFAwXhycG6BHF2aWN07s7GXrnf2QbF9uVvgYEIJawM4h24gjVn_alyiyZs_bLbdHNY7Xv-dPZWnOlpvYnv6fFFfhScq00SH</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Improved mineralization of dental enamel by electrokinetic delivery of F - and Ca 2+ ions</title><source>PubMed (Medline)</source><source>SpringerOpen</source><source>MEDLINE</source><source>Nature Free</source><source>Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Tay, NamBeng ; Gan, HiongYap ; de Sousa, Frederico Barbosa ; Shen, Lu ; Nóbrega, Diego Figueiredo ; Peng, Chenhui ; Kilpatrick-Liverman, LaTonya ; Wang, Wei ; Lavender, Stacey ; Pilch, Shira ; Han, Jongyoon</creator><creatorcontrib>Tay, NamBeng ; Gan, HiongYap ; de Sousa, Frederico Barbosa ; Shen, Lu ; Nóbrega, Diego Figueiredo ; Peng, Chenhui ; Kilpatrick-Liverman, LaTonya ; Wang, Wei ; Lavender, Stacey ; Pilch, Shira ; Han, Jongyoon</creatorcontrib><description>This in vitro study evaluated the effects of the infiltration of F
and Ca
ions into human enamel by electrokinetic flow (EKF) on the enamel microhardness and F
content. Sound human enamel ground sections of unerupted third molars were infiltrated with de-ionized water by EKF and with F
ion by EKF respectively. All samples were submitted to two successive transverse acid-etch biopsies (etching times of 30 s and 20 min) to quantify F
ion infiltrated deep into enamel. Remarkably, sound enamel showed a large increase in microhardness (MH) after infiltration of NaF (p < 0.00001) and CaCl
(p = 0.013) by EKF. Additionally, NaF-EKF increased the remineralization in the lesion body of artificial enamel caries lesions compared to controls (p < 0.01). With the enamel biopsy technique, at both etching times, more F
ions were found in the EKF-treated group than the control group (p << 0.05), and more fluoride was extracted from deeper biopsies in the NaF-EKF group. In conclusion, our results show that EKF treatment is superior in transporting Ca
and F
ions into sound enamel when compared to molecular diffusion, enhancing both the mineralization of sound enamel and the remineralization of artificial enamel caries.</description><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-022-26423-4</identifier><identifier>PMID: 36627315</identifier><language>eng</language><publisher>England</publisher><subject>Cariostatic Agents - pharmacology ; Dental Caries ; Dental Enamel ; Fluorides - pharmacology ; Humans ; Research Design ; Sodium Fluoride ; Tooth Remineralization - methods</subject><ispartof>Scientific reports, 2023-01, Vol.13 (1), p.516</ispartof><rights>2023. The Author(s).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36627315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tay, NamBeng</creatorcontrib><creatorcontrib>Gan, HiongYap</creatorcontrib><creatorcontrib>de Sousa, Frederico Barbosa</creatorcontrib><creatorcontrib>Shen, Lu</creatorcontrib><creatorcontrib>Nóbrega, Diego Figueiredo</creatorcontrib><creatorcontrib>Peng, Chenhui</creatorcontrib><creatorcontrib>Kilpatrick-Liverman, LaTonya</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Lavender, Stacey</creatorcontrib><creatorcontrib>Pilch, Shira</creatorcontrib><creatorcontrib>Han, Jongyoon</creatorcontrib><title>Improved mineralization of dental enamel by electrokinetic delivery of F - and Ca 2+ ions</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>This in vitro study evaluated the effects of the infiltration of F
and Ca
ions into human enamel by electrokinetic flow (EKF) on the enamel microhardness and F
content. Sound human enamel ground sections of unerupted third molars were infiltrated with de-ionized water by EKF and with F
ion by EKF respectively. All samples were submitted to two successive transverse acid-etch biopsies (etching times of 30 s and 20 min) to quantify F
ion infiltrated deep into enamel. Remarkably, sound enamel showed a large increase in microhardness (MH) after infiltration of NaF (p < 0.00001) and CaCl
(p = 0.013) by EKF. Additionally, NaF-EKF increased the remineralization in the lesion body of artificial enamel caries lesions compared to controls (p < 0.01). With the enamel biopsy technique, at both etching times, more F
ions were found in the EKF-treated group than the control group (p << 0.05), and more fluoride was extracted from deeper biopsies in the NaF-EKF group. In conclusion, our results show that EKF treatment is superior in transporting Ca
and F
ions into sound enamel when compared to molecular diffusion, enhancing both the mineralization of sound enamel and the remineralization of artificial enamel caries.</description><subject>Cariostatic Agents - pharmacology</subject><subject>Dental Caries</subject><subject>Dental Enamel</subject><subject>Fluorides - pharmacology</subject><subject>Humans</subject><subject>Research Design</subject><subject>Sodium Fluoride</subject><subject>Tooth Remineralization - methods</subject><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjjGrwjAUhYMgKk__gIPcXfJMbtJqZ1F0d3GSaK8QTdKS9Al9v94KOnuWbzgfh8PYVIpfKdRqkbTMihUXiBxzjYrrHhuh0BlHhThkk5RuokuGhZbFgA1VnuNSyWzEjntfx-pBJXgbKBpn_01jqwDVFUoKjXFAwXhycG6BHF2aWN07s7GXrnf2QbF9uVvgYEIJawM4h24gjVn_alyiyZs_bLbdHNY7Xv-dPZWnOlpvYnv6fFFfhScq00SH</recordid><startdate>20230110</startdate><enddate>20230110</enddate><creator>Tay, NamBeng</creator><creator>Gan, HiongYap</creator><creator>de Sousa, Frederico Barbosa</creator><creator>Shen, Lu</creator><creator>Nóbrega, Diego Figueiredo</creator><creator>Peng, Chenhui</creator><creator>Kilpatrick-Liverman, LaTonya</creator><creator>Wang, Wei</creator><creator>Lavender, Stacey</creator><creator>Pilch, Shira</creator><creator>Han, Jongyoon</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20230110</creationdate><title>Improved mineralization of dental enamel by electrokinetic delivery of F - and Ca 2+ ions</title><author>Tay, NamBeng ; Gan, HiongYap ; de Sousa, Frederico Barbosa ; Shen, Lu ; Nóbrega, Diego Figueiredo ; Peng, Chenhui ; Kilpatrick-Liverman, LaTonya ; Wang, Wei ; Lavender, Stacey ; Pilch, Shira ; Han, Jongyoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_366273153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cariostatic Agents - pharmacology</topic><topic>Dental Caries</topic><topic>Dental Enamel</topic><topic>Fluorides - pharmacology</topic><topic>Humans</topic><topic>Research Design</topic><topic>Sodium Fluoride</topic><topic>Tooth Remineralization - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tay, NamBeng</creatorcontrib><creatorcontrib>Gan, HiongYap</creatorcontrib><creatorcontrib>de Sousa, Frederico Barbosa</creatorcontrib><creatorcontrib>Shen, Lu</creatorcontrib><creatorcontrib>Nóbrega, Diego Figueiredo</creatorcontrib><creatorcontrib>Peng, Chenhui</creatorcontrib><creatorcontrib>Kilpatrick-Liverman, LaTonya</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Lavender, Stacey</creatorcontrib><creatorcontrib>Pilch, Shira</creatorcontrib><creatorcontrib>Han, Jongyoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tay, NamBeng</au><au>Gan, HiongYap</au><au>de Sousa, Frederico Barbosa</au><au>Shen, Lu</au><au>Nóbrega, Diego Figueiredo</au><au>Peng, Chenhui</au><au>Kilpatrick-Liverman, LaTonya</au><au>Wang, Wei</au><au>Lavender, Stacey</au><au>Pilch, Shira</au><au>Han, Jongyoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved mineralization of dental enamel by electrokinetic delivery of F - and Ca 2+ ions</atitle><jtitle>Scientific reports</jtitle><addtitle>Sci Rep</addtitle><date>2023-01-10</date><risdate>2023</risdate><volume>13</volume><issue>1</issue><spage>516</spage><pages>516-</pages><eissn>2045-2322</eissn><abstract>This in vitro study evaluated the effects of the infiltration of F
and Ca
ions into human enamel by electrokinetic flow (EKF) on the enamel microhardness and F
content. Sound human enamel ground sections of unerupted third molars were infiltrated with de-ionized water by EKF and with F
ion by EKF respectively. All samples were submitted to two successive transverse acid-etch biopsies (etching times of 30 s and 20 min) to quantify F
ion infiltrated deep into enamel. Remarkably, sound enamel showed a large increase in microhardness (MH) after infiltration of NaF (p < 0.00001) and CaCl
(p = 0.013) by EKF. Additionally, NaF-EKF increased the remineralization in the lesion body of artificial enamel caries lesions compared to controls (p < 0.01). With the enamel biopsy technique, at both etching times, more F
ions were found in the EKF-treated group than the control group (p << 0.05), and more fluoride was extracted from deeper biopsies in the NaF-EKF group. In conclusion, our results show that EKF treatment is superior in transporting Ca
and F
ions into sound enamel when compared to molecular diffusion, enhancing both the mineralization of sound enamel and the remineralization of artificial enamel caries.</abstract><cop>England</cop><pmid>36627315</pmid><doi>10.1038/s41598-022-26423-4</doi></addata></record> |
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| source | PubMed (Medline); SpringerOpen; MEDLINE; Nature Free; Directory of Open Access Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Cariostatic Agents - pharmacology Dental Caries Dental Enamel Fluorides - pharmacology Humans Research Design Sodium Fluoride Tooth Remineralization - methods |
| title | Improved mineralization of dental enamel by electrokinetic delivery of F - and Ca 2+ ions |
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