Improved hemophagocytic lymphohistiocytosis index predicts prognosis of adult Epstein-Barr virus-associated HLH patients

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a common subtype of HLH with heterogeneous clinical presentations from self-limited to death, of which adults are worse than children. To establish predictors of mortality risk in adult EBV-HLH patients for timely an...

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Veröffentlicht in:	Annals of medicine (Helsinki) 2023-12, Vol.55 (1), p.89-100
Hauptverfasser:	Yao, Shuyan, He, Lingbo, Zhang, Ruoxi, Liu, Menghan, Hua, Zhengjie, Zou, Heshan, Wang, Zhao, Wang, Yini
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Child EBV-associated hemophagocytic lymphohistiocytosis Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - drug therapy Hematology Herpesvirus 4, Human HScore Humans improved hemophagocytic lymphohistiocytosis index improved HLH criteria Lymphohistiocytosis, Hemophagocytic - complications Lymphohistiocytosis, Hemophagocytic - drug therapy Prognosis Retrospective Studies
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Zusammenfassung:	Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a common subtype of HLH with heterogeneous clinical presentations from self-limited to death, of which adults are worse than children. To establish predictors of mortality risk in adult EBV-HLH patients for timely and appropriate treatment. Patients with confirmed EBV-HLH admitted to Beijing Friendship Hospital from January 2015 to December 2019 were enrolled and statistical analysis of their laboratory test results was performed. Among 246 adult patients with EBV-HLH, the deceased were older (p
ISSN:	0785-3890 1365-2060
DOI:	10.1080/07853890.2022.2149850