Response of Isolated Rat Heart to α 2 -Adrenergic Receptor Stimulation after I f Current Blockade in the Late Postinfarction Period

Response of Isolated Rat Heart to α 2 -Adrenergic Receptor Stimulation after I f Current Blockade in the Late Postinfarction Period

We studied the effect of α -adrenoreceptor activation after preliminary I -current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α -adrenoreceptors against the background of application of I blocker ZD7288 in concentrat...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2022-11, Vol.174 (1), p.22
Hauptverfasser: Bugrov, R K, Kuptsova, A M, Ziyatdinova, N I, Zefrov, T L
Format: Artikel
Sprache:eng
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Zusammenfassung:We studied the effect of α -adrenoreceptor activation after preliminary I -current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α -adrenoreceptors against the background of application of I blocker ZD7288 in concentrations of 10 and 10 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p
ISSN:1573-8221
DOI:10.1007/s10517-022-05640-x