Current insights on monitoring of renal transplants-Banff and beyond

Renal transplantation represents the best treatment for end-stage renal disease. Much effort has been invested in improvement of longevity of the transplanted organ including a comprehensive and regularly updated histological scoring system (Banff classification) for surveillance; however, survival of transplanted kidneys is still limited to median 15 years. Molecular analyses have increased the understanding of damaging mechanisms within the transplant, especially antibody-mediated rejection, which can be difficult to identify using histological methods. Changes in the Banff classification necessitate to reclassify biopsies included in studies according to current consensus. Digital and molecular innovations as well as new immunologic mechanisms are anticipated.