Spinal Cord Substrate of the Turning Behavior Induced by Unilateral Lesion of the Entopeduncular Nucleus
The neural pathways in the spinal cord mediating circling behavior in animals with unilateral kainic acid lesion of the entopeduncular nucleus were studied in rats. The circling activity toward the lesioned side was indiced by i.p. administration of apomorphine (3 mg/kg). Section of the lateral funi...
Gespeichert in:
| Veröffentlicht in: | International journal of neuroscience 1987-01, Vol.34 (1-2), p.27-33 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 33 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 27 |
| container_title | International journal of neuroscience |
| container_volume | 34 |
| creator | Pazo, Jorge H. O'donnell, Patricio Murer, Mario G. Gonzalez, Monica Pia, Alejandro |
| description | The neural pathways in the spinal cord mediating circling behavior in animals with unilateral kainic acid lesion of the entopeduncular nucleus were studied in rats. The circling activity toward the lesioned side was indiced by i.p. administration of apomorphine (3 mg/kg). Section of the lateral funiculus ipsilateral to the lesioned entopeduncular nucleus, reduced significantly the rate of drug induced rotations. The above was a common lesion of ventrolateral and dorsolateral transections of the cervical spinal cord. However, the latter transection was more effective than the former to block the circling. On the other hand, lesion of the contralateral spinal cord fails to modify turning behavior. These findings suggest that crossed fibers descending in the dorsolateral quadrant directly from the basal ganglia or mediating synaptic relay in the lower brainstem may be the anatomical substrate of the circling produced by striatal stimulation. |
| doi_str_mv | 10.3109/00207458708985937 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_3610501</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14913279</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-ab2f531d681dfc257d9e6c84f5c4ab7dbd6db3debe1ed2d7153fbefb8b62bb373</originalsourceid><addsrcrecordid>eNqFkU9rFDEYh4Modan9AB6EHMTb1GQyk2TQi11qLSx6aHse8ueNE8kmazKj7Lc3ZbcFEeophN_zvCTvD6HXlJwzSob3hLREdL0URA6yH5h4hla056zpWzE8R6v7vKlA9xKdleJ1vbNhaKU8QSeMU9ITukLTzc5HFfA6ZYtvFl3mrGbAyeF5Any75Ojjd3wBk_rlU8bX0S4GLNZ7fBd9qGiu8gaKT_FBuoxz2oFdolmCyvjrYgIs5RV64VQocHY8T9Hd58vb9Zdm8-3qev1p05iO07lRunU9o5ZLap1pe2EH4EZ2rjed0sJqy61mFjRQsK0VtGdOg9NS81ZrJtgpeneYu8vp5wJlHre-GAhBRUhLGYXghHMy_Bek3UBZ3WQF6QE0OZWSwY277Lcq70dKxvsmxn-aqM6b4_BFb8E-Gse91_ztMVfFqOCyisaXR0y2XErWVuzjAfPRpbxVv1MOdpzVPqT84LCnXvHhL30CFebJqAzjj1SrrT088Yc_lxG3Wg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14913279</pqid></control><display><type>article</type><title>Spinal Cord Substrate of the Turning Behavior Induced by Unilateral Lesion of the Entopeduncular Nucleus</title><source>MEDLINE</source><source>Taylor & Francis Online</source><source>Taylor & Francis Medical Library - CRKN</source><creator>Pazo, Jorge H. ; O'donnell, Patricio ; Murer, Mario G. ; Gonzalez, Monica ; Pia, Alejandro</creator><creatorcontrib>Pazo, Jorge H. ; O'donnell, Patricio ; Murer, Mario G. ; Gonzalez, Monica ; Pia, Alejandro</creatorcontrib><description>The neural pathways in the spinal cord mediating circling behavior in animals with unilateral kainic acid lesion of the entopeduncular nucleus were studied in rats. The circling activity toward the lesioned side was indiced by i.p. administration of apomorphine (3 mg/kg). Section of the lateral funiculus ipsilateral to the lesioned entopeduncular nucleus, reduced significantly the rate of drug induced rotations. The above was a common lesion of ventrolateral and dorsolateral transections of the cervical spinal cord. However, the latter transection was more effective than the former to block the circling. On the other hand, lesion of the contralateral spinal cord fails to modify turning behavior. These findings suggest that crossed fibers descending in the dorsolateral quadrant directly from the basal ganglia or mediating synaptic relay in the lower brainstem may be the anatomical substrate of the circling produced by striatal stimulation.</description><identifier>ISSN: 0020-7454</identifier><identifier>EISSN: 1563-5279</identifier><identifier>EISSN: 1543-5245</identifier><identifier>DOI: 10.3109/00207458708985937</identifier><identifier>PMID: 3610501</identifier><identifier>CODEN: IJNUB7</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Animals ; Apomorphine - pharmacology ; Biological and medical sciences ; Efferent Pathways - physiology ; entropeduncular nucleus ; Fundamental and applied biological sciences. Psychology ; Globus Pallidus - drug effects ; Globus Pallidus - physiology ; Kainic Acid - pharmacology ; Male ; Motor Activity - drug effects ; Motor Activity - physiology ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Rats ; Rats, Inbred Strains ; Rotation ; Spinal Cord - physiology ; spinal cord transection ; turning behavior ; Vertebrates: nervous system and sense organs</subject><ispartof>International journal of neuroscience, 1987-01, Vol.34 (1-2), p.27-33</ispartof><rights>1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-ab2f531d681dfc257d9e6c84f5c4ab7dbd6db3debe1ed2d7153fbefb8b62bb373</citedby><cites>FETCH-LOGICAL-c461t-ab2f531d681dfc257d9e6c84f5c4ab7dbd6db3debe1ed2d7153fbefb8b62bb373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00207458708985937$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00207458708985937$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8268832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3610501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pazo, Jorge H.</creatorcontrib><creatorcontrib>O'donnell, Patricio</creatorcontrib><creatorcontrib>Murer, Mario G.</creatorcontrib><creatorcontrib>Gonzalez, Monica</creatorcontrib><creatorcontrib>Pia, Alejandro</creatorcontrib><title>Spinal Cord Substrate of the Turning Behavior Induced by Unilateral Lesion of the Entopeduncular Nucleus</title><title>International journal of neuroscience</title><addtitle>Int J Neurosci</addtitle><description>The neural pathways in the spinal cord mediating circling behavior in animals with unilateral kainic acid lesion of the entopeduncular nucleus were studied in rats. The circling activity toward the lesioned side was indiced by i.p. administration of apomorphine (3 mg/kg). Section of the lateral funiculus ipsilateral to the lesioned entopeduncular nucleus, reduced significantly the rate of drug induced rotations. The above was a common lesion of ventrolateral and dorsolateral transections of the cervical spinal cord. However, the latter transection was more effective than the former to block the circling. On the other hand, lesion of the contralateral spinal cord fails to modify turning behavior. These findings suggest that crossed fibers descending in the dorsolateral quadrant directly from the basal ganglia or mediating synaptic relay in the lower brainstem may be the anatomical substrate of the circling produced by striatal stimulation.</description><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Efferent Pathways - physiology</subject><subject>entropeduncular nucleus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Globus Pallidus - drug effects</subject><subject>Globus Pallidus - physiology</subject><subject>Kainic Acid - pharmacology</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rotation</subject><subject>Spinal Cord - physiology</subject><subject>spinal cord transection</subject><subject>turning behavior</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0020-7454</issn><issn>1563-5279</issn><issn>1543-5245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFDEYh4Modan9AB6EHMTb1GQyk2TQi11qLSx6aHse8ueNE8kmazKj7Lc3ZbcFEeophN_zvCTvD6HXlJwzSob3hLREdL0URA6yH5h4hla056zpWzE8R6v7vKlA9xKdleJ1vbNhaKU8QSeMU9ITukLTzc5HFfA6ZYtvFl3mrGbAyeF5Any75Ojjd3wBk_rlU8bX0S4GLNZ7fBd9qGiu8gaKT_FBuoxz2oFdolmCyvjrYgIs5RV64VQocHY8T9Hd58vb9Zdm8-3qev1p05iO07lRunU9o5ZLap1pe2EH4EZ2rjed0sJqy61mFjRQsK0VtGdOg9NS81ZrJtgpeneYu8vp5wJlHre-GAhBRUhLGYXghHMy_Bek3UBZ3WQF6QE0OZWSwY277Lcq70dKxvsmxn-aqM6b4_BFb8E-Gse91_ztMVfFqOCyisaXR0y2XErWVuzjAfPRpbxVv1MOdpzVPqT84LCnXvHhL30CFebJqAzjj1SrrT088Yc_lxG3Wg</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>Pazo, Jorge H.</creator><creator>O'donnell, Patricio</creator><creator>Murer, Mario G.</creator><creator>Gonzalez, Monica</creator><creator>Pia, Alejandro</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19870101</creationdate><title>Spinal Cord Substrate of the Turning Behavior Induced by Unilateral Lesion of the Entopeduncular Nucleus</title><author>Pazo, Jorge H. ; O'donnell, Patricio ; Murer, Mario G. ; Gonzalez, Monica ; Pia, Alejandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-ab2f531d681dfc257d9e6c84f5c4ab7dbd6db3debe1ed2d7153fbefb8b62bb373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Efferent Pathways - physiology</topic><topic>entropeduncular nucleus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Globus Pallidus - drug effects</topic><topic>Globus Pallidus - physiology</topic><topic>Kainic Acid - pharmacology</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rotation</topic><topic>Spinal Cord - physiology</topic><topic>spinal cord transection</topic><topic>turning behavior</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pazo, Jorge H.</creatorcontrib><creatorcontrib>O'donnell, Patricio</creatorcontrib><creatorcontrib>Murer, Mario G.</creatorcontrib><creatorcontrib>Gonzalez, Monica</creatorcontrib><creatorcontrib>Pia, Alejandro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pazo, Jorge H.</au><au>O'donnell, Patricio</au><au>Murer, Mario G.</au><au>Gonzalez, Monica</au><au>Pia, Alejandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinal Cord Substrate of the Turning Behavior Induced by Unilateral Lesion of the Entopeduncular Nucleus</atitle><jtitle>International journal of neuroscience</jtitle><addtitle>Int J Neurosci</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>34</volume><issue>1-2</issue><spage>27</spage><epage>33</epage><pages>27-33</pages><issn>0020-7454</issn><eissn>1563-5279</eissn><eissn>1543-5245</eissn><coden>IJNUB7</coden><abstract>The neural pathways in the spinal cord mediating circling behavior in animals with unilateral kainic acid lesion of the entopeduncular nucleus were studied in rats. The circling activity toward the lesioned side was indiced by i.p. administration of apomorphine (3 mg/kg). Section of the lateral funiculus ipsilateral to the lesioned entopeduncular nucleus, reduced significantly the rate of drug induced rotations. The above was a common lesion of ventrolateral and dorsolateral transections of the cervical spinal cord. However, the latter transection was more effective than the former to block the circling. On the other hand, lesion of the contralateral spinal cord fails to modify turning behavior. These findings suggest that crossed fibers descending in the dorsolateral quadrant directly from the basal ganglia or mediating synaptic relay in the lower brainstem may be the anatomical substrate of the circling produced by striatal stimulation.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>3610501</pmid><doi>10.3109/00207458708985937</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7454 |
| ispartof | International journal of neuroscience, 1987-01, Vol.34 (1-2), p.27-33 |
| issn | 0020-7454 1563-5279 1543-5245 |
| language | eng |
| recordid | cdi_pubmed_primary_3610501 |
| source | MEDLINE; Taylor & Francis Online; Taylor & Francis Medical Library - CRKN |
| subjects | Animals Apomorphine - pharmacology Biological and medical sciences Efferent Pathways - physiology entropeduncular nucleus Fundamental and applied biological sciences. Psychology Globus Pallidus - drug effects Globus Pallidus - physiology Kainic Acid - pharmacology Male Motor Activity - drug effects Motor Activity - physiology Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Rats Rats, Inbred Strains Rotation Spinal Cord - physiology spinal cord transection turning behavior Vertebrates: nervous system and sense organs |
| title | Spinal Cord Substrate of the Turning Behavior Induced by Unilateral Lesion of the Entopeduncular Nucleus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T09%3A34%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spinal%20Cord%20Substrate%20of%20the%20Turning%20Behavior%20Induced%20by%20Unilateral%20Lesion%20of%20the%20Entopeduncular%20Nucleus&rft.jtitle=International%20journal%20of%20neuroscience&rft.au=Pazo,%20Jorge%20H.&rft.date=1987-01-01&rft.volume=34&rft.issue=1-2&rft.spage=27&rft.epage=33&rft.pages=27-33&rft.issn=0020-7454&rft.eissn=1563-5279&rft.coden=IJNUB7&rft_id=info:doi/10.3109/00207458708985937&rft_dat=%3Cproquest_pubme%3E14913279%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14913279&rft_id=info:pmid/3610501&rfr_iscdi=true |