Spinal Cord Substrate of the Turning Behavior Induced by Unilateral Lesion of the Entopeduncular Nucleus

The neural pathways in the spinal cord mediating circling behavior in animals with unilateral kainic acid lesion of the entopeduncular nucleus were studied in rats. The circling activity toward the lesioned side was indiced by i.p. administration of apomorphine (3 mg/kg). Section of the lateral funiculus ipsilateral to the lesioned entopeduncular nucleus, reduced significantly the rate of drug induced rotations. The above was a common lesion of ventrolateral and dorsolateral transections of the cervical spinal cord. However, the latter transection was more effective than the former to block the circling. On the other hand, lesion of the contralateral spinal cord fails to modify turning behavior. These findings suggest that crossed fibers descending in the dorsolateral quadrant directly from the basal ganglia or mediating synaptic relay in the lower brainstem may be the anatomical substrate of the circling produced by striatal stimulation.