Sub-toxic events induced by truck speed-facilitated PM 2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells
To distinguish the influences of fuel type and truck speed on chemical composition and sub-toxic effects of particulates (PM ) from engine emissions, biomarkers-interleukin-6 (IL-6), cytochrome P450 (CYP) 1A1, heme oxygenase (HO)-1, and NADPH-quinone oxidoreductase (NQO)-1-were studied in A549 human...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2022-09, Vol.12 (1), p.15004 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 15004 |
| container_title | Scientific reports |
| container_volume | 12 |
| creator | Pan, Shih Yu Chi, Kai Hsien Wang, Yen-Cih Wei, Wen-Chi Ueng, Yune-Fang |
| description | To distinguish the influences of fuel type and truck speed on chemical composition and sub-toxic effects of particulates (PM
) from engine emissions, biomarkers-interleukin-6 (IL-6), cytochrome P450 (CYP) 1A1, heme oxygenase (HO)-1, and NADPH-quinone oxidoreductase (NQO)-1-were studied in A549 human lung cells. Fuel type and truck speed preferentially affected the quantity and ion/polycyclic aromatic hydrocarbon (PAH) composition of PM
, respectively. Under idling operation, phenanthrene was the most abundant PAH. At high speed, more than 50% of the PAHs had high molecular weight (HMW), of which benzo[a]pyrene (B[a]P), benzo[ghi]perylene (B[ghi]P), and indeno[1,2,3-cd]pyrene (I[cd]P) were the main PAHs. B[a]P, B[ghi]P, and I[cd]P caused potent induction of IL-6, CYP1A1, and NQO-1, whereas phenanthrene mildly induced CYP1A1. Based on the PAH-mediated induction, the predicted increases in biomarkers were positively correlated with the measured increases. HMW-PAHs contribute to the biomarker induction by PM
, at high speed, which was reduced by co-exposure to epigallocatechin-3-gallate. |
| doi_str_mv | 10.1038/s41598-022-18918-x |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_36056034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>36056034</sourcerecordid><originalsourceid>FETCH-pubmed_primary_360560343</originalsourceid><addsrcrecordid>eNqFTs1KAzEYDILYon0BD_K9QGp-NmVzFFG8CEK9l2zytU2bzS6bRNon8LVNQc_OZRjmhyHknrMlZ7J9TA1XuqVMCMpbzVt6uiJzwRpFhRRiRhYpHViFErrh-obM5IqpFZPNnHyvS0fzcPIW8AtjTuCjKxYddGfIU7FHSCOio1tjffDZ5Gp9vINYKjDRga8NO5SYcTI2-yFeejj6nQlhsDVt9z5SSS-6qroOT6rRsC-9iRBK3IHFENIdud6akHDxy7fk4fXl8_mNjqXr0W3GyfdmOm_-nst_Az9DSlVl</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Sub-toxic events induced by truck speed-facilitated PM 2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Pan, Shih Yu ; Chi, Kai Hsien ; Wang, Yen-Cih ; Wei, Wen-Chi ; Ueng, Yune-Fang</creator><creatorcontrib>Pan, Shih Yu ; Chi, Kai Hsien ; Wang, Yen-Cih ; Wei, Wen-Chi ; Ueng, Yune-Fang</creatorcontrib><description>To distinguish the influences of fuel type and truck speed on chemical composition and sub-toxic effects of particulates (PM
) from engine emissions, biomarkers-interleukin-6 (IL-6), cytochrome P450 (CYP) 1A1, heme oxygenase (HO)-1, and NADPH-quinone oxidoreductase (NQO)-1-were studied in A549 human lung cells. Fuel type and truck speed preferentially affected the quantity and ion/polycyclic aromatic hydrocarbon (PAH) composition of PM
, respectively. Under idling operation, phenanthrene was the most abundant PAH. At high speed, more than 50% of the PAHs had high molecular weight (HMW), of which benzo[a]pyrene (B[a]P), benzo[ghi]perylene (B[ghi]P), and indeno[1,2,3-cd]pyrene (I[cd]P) were the main PAHs. B[a]P, B[ghi]P, and I[cd]P caused potent induction of IL-6, CYP1A1, and NQO-1, whereas phenanthrene mildly induced CYP1A1. Based on the PAH-mediated induction, the predicted increases in biomarkers were positively correlated with the measured increases. HMW-PAHs contribute to the biomarker induction by PM
, at high speed, which was reduced by co-exposure to epigallocatechin-3-gallate.</description><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-022-18918-x</identifier><identifier>PMID: 36056034</identifier><language>eng</language><publisher>England</publisher><subject>Catechin - analogs & derivatives ; Cytochrome P-450 CYP1A1 ; Dust ; Humans ; Interleukin-6 - pharmacology ; Lung ; Motor Vehicles ; Phenanthrenes - pharmacology ; Polycyclic Aromatic Hydrocarbons - analysis ; Polycyclic Aromatic Hydrocarbons - toxicity</subject><ispartof>Scientific reports, 2022-09, Vol.12 (1), p.15004</ispartof><rights>2022. The Author(s).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36056034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Shih Yu</creatorcontrib><creatorcontrib>Chi, Kai Hsien</creatorcontrib><creatorcontrib>Wang, Yen-Cih</creatorcontrib><creatorcontrib>Wei, Wen-Chi</creatorcontrib><creatorcontrib>Ueng, Yune-Fang</creatorcontrib><title>Sub-toxic events induced by truck speed-facilitated PM 2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>To distinguish the influences of fuel type and truck speed on chemical composition and sub-toxic effects of particulates (PM
) from engine emissions, biomarkers-interleukin-6 (IL-6), cytochrome P450 (CYP) 1A1, heme oxygenase (HO)-1, and NADPH-quinone oxidoreductase (NQO)-1-were studied in A549 human lung cells. Fuel type and truck speed preferentially affected the quantity and ion/polycyclic aromatic hydrocarbon (PAH) composition of PM
, respectively. Under idling operation, phenanthrene was the most abundant PAH. At high speed, more than 50% of the PAHs had high molecular weight (HMW), of which benzo[a]pyrene (B[a]P), benzo[ghi]perylene (B[ghi]P), and indeno[1,2,3-cd]pyrene (I[cd]P) were the main PAHs. B[a]P, B[ghi]P, and I[cd]P caused potent induction of IL-6, CYP1A1, and NQO-1, whereas phenanthrene mildly induced CYP1A1. Based on the PAH-mediated induction, the predicted increases in biomarkers were positively correlated with the measured increases. HMW-PAHs contribute to the biomarker induction by PM
, at high speed, which was reduced by co-exposure to epigallocatechin-3-gallate.</description><subject>Catechin - analogs & derivatives</subject><subject>Cytochrome P-450 CYP1A1</subject><subject>Dust</subject><subject>Humans</subject><subject>Interleukin-6 - pharmacology</subject><subject>Lung</subject><subject>Motor Vehicles</subject><subject>Phenanthrenes - pharmacology</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFTs1KAzEYDILYon0BD_K9QGp-NmVzFFG8CEK9l2zytU2bzS6bRNon8LVNQc_OZRjmhyHknrMlZ7J9TA1XuqVMCMpbzVt6uiJzwRpFhRRiRhYpHViFErrh-obM5IqpFZPNnHyvS0fzcPIW8AtjTuCjKxYddGfIU7FHSCOio1tjffDZ5Gp9vINYKjDRga8NO5SYcTI2-yFeejj6nQlhsDVt9z5SSS-6qroOT6rRsC-9iRBK3IHFENIdud6akHDxy7fk4fXl8_mNjqXr0W3GyfdmOm_-nst_Az9DSlVl</recordid><startdate>20220902</startdate><enddate>20220902</enddate><creator>Pan, Shih Yu</creator><creator>Chi, Kai Hsien</creator><creator>Wang, Yen-Cih</creator><creator>Wei, Wen-Chi</creator><creator>Ueng, Yune-Fang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20220902</creationdate><title>Sub-toxic events induced by truck speed-facilitated PM 2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells</title><author>Pan, Shih Yu ; Chi, Kai Hsien ; Wang, Yen-Cih ; Wei, Wen-Chi ; Ueng, Yune-Fang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_360560343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Catechin - analogs & derivatives</topic><topic>Cytochrome P-450 CYP1A1</topic><topic>Dust</topic><topic>Humans</topic><topic>Interleukin-6 - pharmacology</topic><topic>Lung</topic><topic>Motor Vehicles</topic><topic>Phenanthrenes - pharmacology</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Shih Yu</creatorcontrib><creatorcontrib>Chi, Kai Hsien</creatorcontrib><creatorcontrib>Wang, Yen-Cih</creatorcontrib><creatorcontrib>Wei, Wen-Chi</creatorcontrib><creatorcontrib>Ueng, Yune-Fang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Shih Yu</au><au>Chi, Kai Hsien</au><au>Wang, Yen-Cih</au><au>Wei, Wen-Chi</au><au>Ueng, Yune-Fang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sub-toxic events induced by truck speed-facilitated PM 2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells</atitle><jtitle>Scientific reports</jtitle><addtitle>Sci Rep</addtitle><date>2022-09-02</date><risdate>2022</risdate><volume>12</volume><issue>1</issue><spage>15004</spage><pages>15004-</pages><eissn>2045-2322</eissn><abstract>To distinguish the influences of fuel type and truck speed on chemical composition and sub-toxic effects of particulates (PM
) from engine emissions, biomarkers-interleukin-6 (IL-6), cytochrome P450 (CYP) 1A1, heme oxygenase (HO)-1, and NADPH-quinone oxidoreductase (NQO)-1-were studied in A549 human lung cells. Fuel type and truck speed preferentially affected the quantity and ion/polycyclic aromatic hydrocarbon (PAH) composition of PM
, respectively. Under idling operation, phenanthrene was the most abundant PAH. At high speed, more than 50% of the PAHs had high molecular weight (HMW), of which benzo[a]pyrene (B[a]P), benzo[ghi]perylene (B[ghi]P), and indeno[1,2,3-cd]pyrene (I[cd]P) were the main PAHs. B[a]P, B[ghi]P, and I[cd]P caused potent induction of IL-6, CYP1A1, and NQO-1, whereas phenanthrene mildly induced CYP1A1. Based on the PAH-mediated induction, the predicted increases in biomarkers were positively correlated with the measured increases. HMW-PAHs contribute to the biomarker induction by PM
, at high speed, which was reduced by co-exposure to epigallocatechin-3-gallate.</abstract><cop>England</cop><pmid>36056034</pmid><doi>10.1038/s41598-022-18918-x</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2045-2322 |
| ispartof | Scientific reports, 2022-09, Vol.12 (1), p.15004 |
| issn | 2045-2322 |
| language | eng |
| recordid | cdi_pubmed_primary_36056034 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Catechin - analogs & derivatives Cytochrome P-450 CYP1A1 Dust Humans Interleukin-6 - pharmacology Lung Motor Vehicles Phenanthrenes - pharmacology Polycyclic Aromatic Hydrocarbons - analysis Polycyclic Aromatic Hydrocarbons - toxicity |
| title | Sub-toxic events induced by truck speed-facilitated PM 2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T03%3A37%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sub-toxic%20events%20induced%20by%20truck%20speed-facilitated%20PM%202.5%20and%20its%20counteraction%20by%20epigallocatechin-3-gallate%20in%20A549%20human%20lung%20cells&rft.jtitle=Scientific%20reports&rft.au=Pan,%20Shih%20Yu&rft.date=2022-09-02&rft.volume=12&rft.issue=1&rft.spage=15004&rft.pages=15004-&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-022-18918-x&rft_dat=%3Cpubmed%3E36056034%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/36056034&rfr_iscdi=true |