The role of the response to DNA damage in granulomatous diseases
Granulomas are organized aggregates of immune cells, which are formed in response to a persistent stimulus and are found in various rheumatic diseases, including sarcoidosis, rheumatoid arthritis and granulomatosis with polyangiitis. The core of granulomas contains a multitude of different macrophag...
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Veröffentlicht in: | Zeitschrift für Rheumatologie 2022-12, Vol.81 (10), p.881 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | ger |
Online-Zugang: | Volltext |
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Zusammenfassung: | Granulomas are organized aggregates of immune cells, which are formed in response to a persistent stimulus and are found in various rheumatic diseases, including sarcoidosis, rheumatoid arthritis and granulomatosis with polyangiitis. The core of granulomas contains a multitude of different macrophage subtypes, including multinucleated macrophages and foam cells. The mechanisms which induce the formation of granulomas are not well understood; however, recent data show that the DNA damage response regulates granuloma macrophage differentiation. |
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ISSN: | 1435-1250 |
DOI: | 10.1007/s00393-022-01260-y |