Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias and disrupts the fine-tuning of G i/o signaling

Cardiac contractility, essential to maintaining proper cardiac output and circulation, is regulated by G protein-coupled receptor (GPCR) signaling. Previously, the absence of regulator of G protein signaling (RGS) 2 and 5, separately, was shown to cause G protein dysregulation, contributing to modes...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2022-09, Vol.170, p.34
Hauptverfasser:	Dahlen, Shelby A, Bernadyn, Tyler F, Dixon, Alethia J, Sun, Bo, Xia, Jingsheng, Owens, Elizabeth A, Osei-Owusu, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - metabolism Cardiomegaly - metabolism GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Male Mice Myocytes, Cardiac - metabolism RGS Proteins - genetics RGS Proteins - metabolism Signal Transduction
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