Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR

Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR

A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compou...

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Veröffentlicht in:RSC advances 2020-11, Vol.1 (67), p.41197-4121
Hauptverfasser: Uppala, Sivaranjan, Gamliel, Ayelet, Sapir, Gal, Sosna, Jacob, Gomori, J. Moshe, Katz-Brull, Rachel
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Depolarization
Exchanging
Glucose
NMR
Nuclear magnetic resonance
Rate constants
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Zusammenfassung:A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compound. The forward to reverse reaction rate constants ratio was ca. 1.6. A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra08022e