Predictive value of clinical and 18 F-FDG-PET/CT derived imaging parameters in patients undergoing neoadjuvant chemoradiation for esophageal squamous cell carcinoma

Aim of this study was to validate the prognostic impact of clinical parameters and baseline F-FDG-PET/CT derived textural features to predict histopathologic response and survival in patients with esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiation (nCRT) and surgery. Between 20...

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Veröffentlicht in:	Scientific reports 2022-05, Vol.12 (1), p.7148
Hauptverfasser:	Marr, Lisa, Haller, Bernhard, Pyka, Thomas, Peeken, Jan C, Jesinghaus, Moritz, Scheidhauer, Klemens, Friess, Helmut, Combs, Stephanie E, Münch, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - therapy Esophageal Squamous Cell Carcinoma - diagnostic imaging Esophageal Squamous Cell Carcinoma - therapy Fluorodeoxyglucose F18 - metabolism Humans Multimodal Imaging - methods Neoadjuvant Therapy Neoplasm, Residual Positron Emission Tomography Computed Tomography - methods Radiopharmaceuticals - metabolism
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Zusammenfassung:	Aim of this study was to validate the prognostic impact of clinical parameters and baseline F-FDG-PET/CT derived textural features to predict histopathologic response and survival in patients with esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiation (nCRT) and surgery. Between 2005 and 2014, 38 ESCC were treated with nCRT and surgery. For all patients, the F-FDG-PET-derived parameters metabolic tumor volume (MTV), SUVmax, contrast and busyness were calculated for the primary tumor using a SUV-threshold of 3. The parameter uniformity was calculated using contrast-enhanced computed tomography. Based on histopathological response to nCRT, patients were classified as good responders (
ISSN:	2045-2322