Mitotic WNT: aligning chromosomes through KIF2A

Mitotic WNT: aligning chromosomes through KIF2A

WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure proper chromosome alignment during mitosis th...

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Veröffentlicht in:Molecular & cellular oncology 2021-11, Vol.8 (6), p.2011564-2011564
Hauptverfasser: Bufe, Anja, Acebrón, Sergio P.
Format: Artikel
Sprache:eng
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chromosome congression
disheveled
kinesin-13
PLK1
WNT signaling
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Zusammenfassung:WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure proper chromosome alignment during mitosis through the regulation of kinesin family member 2A (KIF2A).
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2021.2011564