EXPERIMENTAL JUSTIFICATION OF CORRECTIVE ACTION OF NATIVE AND SELENIUM-MODIFIED MINERAL WATERS ON METABOLIC SYNDROME MODEL

The purpose of the study was to determine the effect of native and selenium-modified mineral waters on metabolic syndrome models. Combined metabolic syndrome (combMS) was simulated in 70 white rats of male gender under standard vivarium conditions, using high-calorie food and single administration of streptozotocin. During the random sampling study the following groups of animals were formed: in the control group 1 (n=6) the rats had standard forage during the experiment; in the control group 2 (n=10) there were rats with combMS model without treatment; in the main groups, starting at the 61st day of combMS, the rats received: the 1st group (n=11) - Essentuki mineral water №4; the 2nd (n=16) - the same water with selenium; in the 3rd (n=11) - Slavyanovskaya mineral water; in the 4th (n=16) - Slavyanovskaya with selenium. Registration of the effects was determined by carbohydrate, protein and lipid metabolism. Metabolic syndrome was monitored by recording animal weight gain and the level of glycemia by the express method at the beginning and the end of the treatment course. As a result, in main groups glucose increased 1.5-2 times, urea and lactate - 1.5 times, triglycerides - 30-40% compared, to the data in the control group 1, against the background of reduced content of contrinsular hormones. All the animals with combMS (control 2 and all the main groups) increased α-amylase activity. The most significant corrective parameters of the metabolic syndrome were established: in the main group 1 - a decrease in hyperglycemia, in the 3rd main group - urea, and in the main groups 2 and 4 the lipid spectrum recovered and the level of lactate decreased. Modification of different mineral waters by selenium provides leveling of differences between them in therapeutic effectiveness.