Unusual Resistance Mechanisms in a Case of ROS 1 -Rearranged NSCLC: A Case Report

Unusual Resistance Mechanisms in a Case of ROS 1 -Rearranged NSCLC: A Case Report

The unprecedented growth of the high-throughput next-generation sequencing has facilitated the identification of rare oncogene fusions such as for NSCLC. rearrangement has been observed in only 2% of cases of NSCLC and has been successfully targeted using various tyrosine kinase inhibitors including...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:JTO clinical and research reports 2022-03, Vol.3 (3), p.100286
Hauptverfasser: Batra, Ullas, Nathany, Shrinidhi, Sharma, Mansi, Mattoo, Sakshi, Jose, Joslia T, Mehta, Anurag
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The unprecedented growth of the high-throughput next-generation sequencing has facilitated the identification of rare oncogene fusions such as for NSCLC. rearrangement has been observed in only 2% of cases of NSCLC and has been successfully targeted using various tyrosine kinase inhibitors including crizotinib. However, the on-target and off-target mechanisms of the resistance are still vague. Here, we report a case of a patient with rearranged NSCLC presenting primary resistance to crizotinib.
ISSN:2666-3643