Peptide probes for proteases - innovations and applications for monitoring proteolytic activity

Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo. From a chemistry-based perspective, this review discusses the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo .