Effects of aflatoxin on the cellular immune system

Observations of aflatoxin induced thymic involution were followed by studies of other parameters of cellular immunity. Guinea pigs treated with 0.03 to 0.35 mg aflatoxin Bi for 3 to 5 weeks were tested for the development of cutaneous hyperssnsitivity, migration inhibition factor activity, and stimu...

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Veröffentlicht in:	Annales de la nutrition et de l'alimentation 1977, Vol.31 (4/6), p.781-897
Hauptverfasser:	Pier, A.C, Fichtner, R.E, Cysewski, S.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxins - pharmacology Animals DEUXIÈME PARTIE: TOXICITÉ MÉCANISME D'ACTION MÉTABOLISME, SANTÉ PUBLIQUE Guinea Pigs Immunity, Cellular Lymphocyte Activation Macrophage Migration-Inhibitory Factors - biosynthesis
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Zusammenfassung:	Observations of aflatoxin induced thymic involution were followed by studies of other parameters of cellular immunity. Guinea pigs treated with 0.03 to 0.35 mg aflatoxin Bi for 3 to 5 weeks were tested for the development of cutaneous hyperssnsitivity, migration inhibition factor activity, and stimulation of lymphocyte transformation. A significant suppression of cutaneous hypersensitivity to a Nocardia asteroides sensitin in sensitized aflatoxin recipients was demonstrated. In vitro reductions in migration inhibition factor (MIF) and depressed stimulation indices (Phytohemagglutinin) of peripheral blood lymphocytes were also demonstrated in aflatoxin recipients but did not reach significant levels.
ISSN:	0003-4037