Distinctive ionic transport of freshly excised human epileptogenic brain tissue

Distinctive ionic transport of freshly excised human epileptogenic brain tissue

Epileptogenic lesions have higher concentrations of sodium than does normal brain tissue. Such lesions are palpably recognized by a surgeon and then excised in order to eliminate epileptic seizures with their associated abnormal electrical behavior. Here, we study the frequency-dependent electrical...

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Veröffentlicht in:Applied physics letters 2021-12, Vol.119 (25), p.253701-253701
Hauptverfasser: Emin, David, Fallah, Aria, Salamon, Noriko, Mathern, Gary, Akhtari, Massoud
Format: Artikel
Sprache:eng
Schlagworte:
Applied physics
Biophysics, Bioimaging, and Biosensors
Brain
Cations
Diffusion barriers
Diffusion rate
Epilepsy
Lesions
Saturation
Seizures
Sodium
Tissues
Tumors
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Zusammenfassung:Epileptogenic lesions have higher concentrations of sodium than does normal brain tissue. Such lesions are palpably recognized by a surgeon and then excised in order to eliminate epileptic seizures with their associated abnormal electrical behavior. Here, we study the frequency-dependent electrical conductivities of lesion-laden tissues excised from the brains of epilepsy patients. The low-frequency (
ISSN:0003-6951
1077-3118
DOI:10.1063/5.0077825