Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast

Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast

Abstract Squamous cell carcinoma (SCC) of the breast is a rare malignancy that usually has a triple-negative phenotype and poor clinical outcomes. Because HER2-positive SCC of the breast is extremely rare, its clinicopathologic features are understudied, and the effects of neoadjuvant chemotherapy i...

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Veröffentlicht in:Case Reports in Oncology 2021-10, Vol.14 (3), p.1536-1541
Hauptverfasser: Usui, Yuki, Matsunuma, Ryoichi, Yamaguchi, Kei, Hayami, Ryosuke, Muramatsu, Aya, Suzuki, Makoto, Tsuneizumi, Michiko
Format: Artikel
Sprache:eng
Schlagworte:
Abscesses
Antimitotic agents
Antineoplastic agents
Breast cancer
Case Report
Case reports
Chemotherapy
Cytokeratin
Dosage and administration
Lymphatic system
Magnetic resonance imaging
Mammography
Medical prognosis
Metastasis
Neoadjuvant therapy
pathological complete response
Patient outcomes
Squamous cell carcinoma
Tomography
Transplants & implants
Treatment resistance
Ultrasonic imaging
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Zusammenfassung:Abstract Squamous cell carcinoma (SCC) of the breast is a rare malignancy that usually has a triple-negative phenotype and poor clinical outcomes. Because HER2-positive SCC of the breast is extremely rare, its clinicopathologic features are understudied, and the effects of neoadjuvant chemotherapy including anti-HER2-targeted therapy on the tumor are unclear, although treatment resistance was described in some reports. In this study, we reported a case of HER2-positive SCC of the breast in which a pathological complete response to neoadjuvant chemotherapy was observed.
ISSN:1662-6575
1662-6575
DOI:10.1159/000519746