EFFECTS OF DIETHYLSTILBESTROL DIPHOSPHATE (DES-P) AND ALPHA-INTERFERON ON NATURAL KILLER CELL ACTIVITY IN VITRO

EFFECTS OF DIETHYLSTILBESTROL DIPHOSPHATE (DES-P) AND ALPHA-INTERFERON ON NATURAL KILLER CELL ACTIVITY IN VITRO

Estrogens have been considered to affect several features of the immune system: Delayed hypersensitivity reaction, mitogen responsiveness, antibody production and natural killer (NK) cell activity. It has recently been shown that long term treatment with diethylstilbestrol diphosphate (DES-P), an es...

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Veröffentlicht in:Nippon Hinyokika Gakkai zasshi 1987/10/20, Vol.78(10), pp.1707-1716
Hauptverfasser: Ueno, Munehisa, Marumo, Ken, Muraki, Junro, Baba, Siro, Murai, Masaru, Tazaki, Hiroshi, Yamamoto, Yasuhide
Format: Artikel
Sprache:jpn
Schlagworte:
Antineoplastic Agents - pharmacology
Diethylstilbestrol - analogs & derivatives
Diethylstilbestrol - pharmacology
Humans
Interferon Type I - pharmacology
Killer Cells, Natural - drug effects
Male
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - immunology
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Zusammenfassung:Estrogens have been considered to affect several features of the immune system: Delayed hypersensitivity reaction, mitogen responsiveness, antibody production and natural killer (NK) cell activity. It has recently been shown that long term treatment with diethylstilbestrol diphosphate (DES-P), an estrogenic agent, reduces NK cell activity in mice. We examined if DES-P wolud suppress NK cell activity in patients with prostatic cancer on basis of earlier reports. Five hundred mg of intravenous DES-P treatment resulted in significant suppression of NK cell activity (from 67.4±9.4% to 43.8±11.8%, p
ISSN:0021-5287
1884-7110
DOI:10.5980/jpnjurol1928.78.10_1707