CTCF is a barrier for 2C-like reprogramming

Totipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from ESC and display similar features to those found in...

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Veröffentlicht in:	Nature communications 2021-08, Vol.12 (1), p.4856-4856, Article 4856
Hauptverfasser:	Olbrich, Teresa, Vega-Sendino, Maria, Tillo, Desiree, Wu, Wei, Zolnerowich, Nicholas, Pavani, Raphael, Tran, Andy D., Domingo, Catherine N., Franco, Mariajose, Markiewicz-Potoczny, Marta, Pegoraro, Gianluca, FitzGerald, Peter C., Kruhlak, Michael J., Lazzerini-Denchi, Eros, Nora, Elphege P., Nussenzweig, André, Ruiz, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/63 45/100 45/15 45/22 45/23 45/41 45/77 45/90 631/136/2444 631/337/100 631/532/2062 96/1 Animals Binding Sites CCCTC-Binding Factor - genetics CCCTC-Binding Factor - metabolism Cell Death Cellular Reprogramming Conversion Damage Deoxyribonucleic acid Depletion DNA DNA Damage Embryo cells Embryo, Mammalian Embryos Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humanities and Social Sciences Mice multidisciplinary Neural stem cells Pluripotency Progenitor cells Science Science (multidisciplinary) Stem cells Totipotent Stem Cells - cytology Totipotent Stem Cells - metabolism Transcription activation Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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