8-Hydroxyquinolin-2(1H)-one analogues as potential β 2 -agonists: Design, synthesis and activity study

β -Agonists that bind to plasmalemmal β -adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β -agonistic activities with a cellular cAMP assay...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-11, Vol.224, p.113697
Hauptverfasser:	Xing, Gang, Zhi, Zhengxing, Yi, Ce, Zou, Jitian, Jing, Xuefeng, Yiu-Ho Woo, Anthony, Lin, Bin, Pan, Li, Zhang, Yuyang, Cheng, Maosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Drug Design Guinea Pigs HEK293 Cells Humans Models, Molecular Molecular Structure Receptors, Adrenergic, beta-2 - metabolism Structure-Activity Relationship
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Zusammenfassung:	β -Agonists that bind to plasmalemmal β -adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β -agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC
ISSN:	1768-3254