Age- and gender-related differences in brain tissue microstructure revealed by multi-component T 2 relaxometry
In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. Here, we performed the largest Multi-component T relaxometry cross-sect...
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| Veröffentlicht in: | Neurobiology of aging 2021-10, Vol.106, p.68 |
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| creator | Canales-Rodríguez, Erick Jorge Alonso-Lana, Silvia Verdolini, Norma Sarró, Salvador Feria, Isabel Montoro, Irene Garcia-Ruiz, Beatriz Jimenez, Esther Varo, Cristina Albacete, Auria Argila-Plaza, Isabel Lluch, Anna Bonnin, C Mar Vilella, Elisabet Vieta, Eduard Pomarol-Clotet, Edith Salvador, Raymond |
| description | In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. Here, we performed the largest Multi-component T
relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T
spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T
relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter. Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women. |
| doi_str_mv | 10.1016/j.neurobiolaging.2021.06.002 |
| format | Article |
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relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T
spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T
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relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T
spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T
relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter. Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroimaging - methods</subject><subject>Sex Characteristics</subject><subject>Young Adult</subject><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j0FLwzAYhoMgbk7_guTgNfVL0ibtcQx1wsDLPI-k_Voy2rQkqbh_b0W9vO_pfXgfQh45ZBy4ejpnHucwWjf2pnO-ywQInoHKAMQVWfOiKBnPK70itzGeAUDnWt2QlcxFIUot18RvO2TU-IZ26BsMLGBvEja0cW2LAX2NkTpPbTBLJhfjjHRwdRhjCnOd5oA04CeaftnYCx3mPjlWj8M0evSJHqmgP8ivccAULnfkujV9xPu_3pCPl-fjbs8O769vu-2BTRzKxDQUVrdWQquFqkwDOeflcl8JWWBbWdXKWluoFrUyrwVIkCpXymptpVYG5IY8_HKn2Q7YnKbgBhMup39x-Q26CV5i</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Canales-Rodríguez, Erick Jorge</creator><creator>Alonso-Lana, Silvia</creator><creator>Verdolini, Norma</creator><creator>Sarró, Salvador</creator><creator>Feria, Isabel</creator><creator>Montoro, Irene</creator><creator>Garcia-Ruiz, Beatriz</creator><creator>Jimenez, Esther</creator><creator>Varo, Cristina</creator><creator>Albacete, Auria</creator><creator>Argila-Plaza, Isabel</creator><creator>Lluch, Anna</creator><creator>Bonnin, C Mar</creator><creator>Vilella, Elisabet</creator><creator>Vieta, Eduard</creator><creator>Pomarol-Clotet, Edith</creator><creator>Salvador, Raymond</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202110</creationdate><title>Age- and gender-related differences in brain tissue microstructure revealed by multi-component T 2 relaxometry</title><author>Canales-Rodríguez, Erick Jorge ; Alonso-Lana, Silvia ; Verdolini, Norma ; Sarró, Salvador ; Feria, Isabel ; Montoro, Irene ; Garcia-Ruiz, Beatriz ; Jimenez, Esther ; Varo, Cristina ; Albacete, Auria ; Argila-Plaza, Isabel ; Lluch, Anna ; Bonnin, C Mar ; Vilella, Elisabet ; Vieta, Eduard ; Pomarol-Clotet, Edith ; Salvador, Raymond</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p108t-705b7fb30f7269ad041180006235ef9b6f3c7b0949784c203036466b77b376a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - pathology</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroimaging - methods</topic><topic>Sex Characteristics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canales-Rodríguez, Erick Jorge</creatorcontrib><creatorcontrib>Alonso-Lana, Silvia</creatorcontrib><creatorcontrib>Verdolini, Norma</creatorcontrib><creatorcontrib>Sarró, Salvador</creatorcontrib><creatorcontrib>Feria, Isabel</creatorcontrib><creatorcontrib>Montoro, Irene</creatorcontrib><creatorcontrib>Garcia-Ruiz, Beatriz</creatorcontrib><creatorcontrib>Jimenez, Esther</creatorcontrib><creatorcontrib>Varo, Cristina</creatorcontrib><creatorcontrib>Albacete, Auria</creatorcontrib><creatorcontrib>Argila-Plaza, Isabel</creatorcontrib><creatorcontrib>Lluch, Anna</creatorcontrib><creatorcontrib>Bonnin, C Mar</creatorcontrib><creatorcontrib>Vilella, Elisabet</creatorcontrib><creatorcontrib>Vieta, Eduard</creatorcontrib><creatorcontrib>Pomarol-Clotet, Edith</creatorcontrib><creatorcontrib>Salvador, Raymond</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canales-Rodríguez, Erick Jorge</au><au>Alonso-Lana, Silvia</au><au>Verdolini, Norma</au><au>Sarró, Salvador</au><au>Feria, Isabel</au><au>Montoro, Irene</au><au>Garcia-Ruiz, Beatriz</au><au>Jimenez, Esther</au><au>Varo, Cristina</au><au>Albacete, Auria</au><au>Argila-Plaza, Isabel</au><au>Lluch, Anna</au><au>Bonnin, C Mar</au><au>Vilella, Elisabet</au><au>Vieta, Eduard</au><au>Pomarol-Clotet, Edith</au><au>Salvador, Raymond</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age- and gender-related differences in brain tissue microstructure revealed by multi-component T 2 relaxometry</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2021-10</date><risdate>2021</risdate><volume>106</volume><spage>68</spage><pages>68-</pages><eissn>1558-1497</eissn><abstract>In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. 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relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T
spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T
relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter. Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women.</abstract><cop>United States</cop><pmid>34252873</pmid><doi>10.1016/j.neurobiolaging.2021.06.002</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Aging - pathology Brain - diagnostic imaging Brain - pathology Child Child, Preschool Cross-Sectional Studies Female Humans Magnetic Resonance Imaging - methods Male Middle Aged Neuroimaging - methods Sex Characteristics Young Adult |
| title | Age- and gender-related differences in brain tissue microstructure revealed by multi-component T 2 relaxometry |
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