Placental transfer of monoclonal antibodies: The example of anti-TNF alpha drugs

Anti-TNF alpha monoclonal antibodies are used in the treatment of chronic inflammatory diseases, which commonly affect women of childbearing age. Due to their similar structure to native immunoglobulins, the evaluation of their placental transfer by a pharmacological approach of the mechanisms invol...

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Veröffentlicht in:	Gynécologie, obstétrique, fertilité & sénologie obstétrique, fertilité & sénologie, 2021-09, Vol.49 (9), p.724
1. Verfasser:	Beghin, D
Format:	Artikel
Sprache:	eng ; fre
Schlagworte:	Antibodies, Monoclonal - pharmacokinetics Female Humans Maternal-Fetal Exchange Placenta Pregnancy Tumor Necrosis Factor Inhibitors - pharmacokinetics
Online-Zugang:	Volltext
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Zusammenfassung:	Anti-TNF alpha monoclonal antibodies are used in the treatment of chronic inflammatory diseases, which commonly affect women of childbearing age. Due to their similar structure to native immunoglobulins, the evaluation of their placental transfer by a pharmacological approach of the mechanisms involved is an interesting source of information, useful to the risk-benefit assessment of drugs in pregnant women.
ISSN:	2468-7189
DOI:	10.1016/j.gofs.2021.06.008