Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes
An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascul...
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| Veröffentlicht in: | The New England journal of medicine 2021-07, Vol.385 (1), p.23-34 |
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| container_title | The New England journal of medicine |
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| creator | Son, Mary Beth F Murray, Nancy Friedman, Kevin Young, Cameron C Newhams, Margaret M Feldstein, Leora R Loftis, Laura L Tarquinio, Keiko M Singh, Aalok R Heidemann, Sabrina M Soma, Vijaya L Riggs, Becky J Fitzgerald, Julie C Kong, Michele Doymaz, Sule Giuliano, John S Keenaghan, Michael A Hume, Janet R Hobbs, Charlotte V Schuster, Jennifer E Clouser, Katharine N Hall, Mark W Smith, Lincoln S Horwitz, Steven M Schwartz, Stephanie P Irby, Katherine Bradford, Tamara T Maddux, Aline B Babbitt, Christopher J Rowan, Courtney M McLaughlin, Gwenn E Yager, Phoebe H Maamari, Mia Mack, Elizabeth H Carroll, Christopher L Montgomery, Vicki L Halasa, Natasha B Cvijanovich, Natalie Z Coates, Bria M Rose, Charles E Newburger, Jane W Patel, Manish M Randolph, Adrienne G |
| description | An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascular dysfunction and a lower incidence of adjunctive therapy use than IVIG alone. |
| doi_str_mv | 10.1056/NEJMoa2102605 |
| format | Article |
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Murray, Nancy ; Friedman, Kevin ; Young, Cameron C ; Newhams, Margaret M ; Feldstein, Leora R ; Loftis, Laura L ; Tarquinio, Keiko M ; Singh, Aalok R ; Heidemann, Sabrina M ; Soma, Vijaya L ; Riggs, Becky J ; Fitzgerald, Julie C ; Kong, Michele ; Doymaz, Sule ; Giuliano, John S ; Keenaghan, Michael A ; Hume, Janet R ; Hobbs, Charlotte V ; Schuster, Jennifer E ; Clouser, Katharine N ; Hall, Mark W ; Smith, Lincoln S ; Horwitz, Steven M ; Schwartz, Stephanie P ; Irby, Katherine ; Bradford, Tamara T ; Maddux, Aline B ; Babbitt, Christopher J ; Rowan, Courtney M ; McLaughlin, Gwenn E ; Yager, Phoebe H ; Maamari, Mia ; Mack, Elizabeth H ; Carroll, Christopher L ; Montgomery, Vicki L ; Halasa, Natasha B ; Cvijanovich, Natalie Z ; Coates, Bria M ; Rose, Charles E ; Newburger, Jane W ; Patel, Manish M ; Randolph, Adrienne G</creator><creatorcontrib>Son, Mary Beth F ; Murray, Nancy ; Friedman, Kevin ; Young, Cameron C ; Newhams, Margaret M ; Feldstein, Leora R ; Loftis, Laura L ; Tarquinio, Keiko M ; Singh, Aalok R ; Heidemann, Sabrina M ; Soma, Vijaya L ; Riggs, Becky J ; Fitzgerald, Julie C ; Kong, Michele ; Doymaz, Sule ; Giuliano, John S ; Keenaghan, Michael A ; Hume, Janet R ; Hobbs, Charlotte V ; Schuster, Jennifer E ; Clouser, Katharine N ; Hall, Mark W ; Smith, Lincoln S ; Horwitz, Steven M ; Schwartz, Stephanie P ; Irby, Katherine ; Bradford, Tamara T ; Maddux, Aline B ; Babbitt, Christopher J ; Rowan, Courtney M ; McLaughlin, Gwenn E ; Yager, Phoebe H ; Maamari, Mia ; Mack, Elizabeth H ; Carroll, Christopher L ; Montgomery, Vicki L ; Halasa, Natasha B ; Cvijanovich, Natalie Z ; Coates, Bria M ; Rose, Charles E ; Newburger, Jane W ; Patel, Manish M ; Randolph, Adrienne G ; Overcoming COVID-19 Investigators</creatorcontrib><description>An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascular dysfunction and a lower incidence of adjunctive therapy use than IVIG alone.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2102605</identifier><identifier>PMID: 34133855</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adolescent ; Allergy ; Aneurysms ; Biological products ; Body temperature ; Cardiovascular diseases ; Child ; Child, Preschool ; Childhood Diseases ; Children ; Cohort Studies ; Combined Modality Therapy ; Coronary vessels ; Coronavirus ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - drug therapy ; COVID-19 - immunology ; COVID-19 - mortality ; Cytokines ; Disease control ; Drug Therapy, Combination ; Female ; Fever ; Globulins ; Glucocorticoids ; Glucocorticoids - therapeutic use ; Health surveillance ; Heart ; Hospitalization ; Humans ; Immunoglobulins ; Immunoglobulins, Intravenous - therapeutic use ; Immunology ; Immunology General ; Immunomodulation ; Infant ; Infectious Disease ; Inflammation ; Intravenous administration ; Length of stay ; Logistic Models ; Male ; Medical laboratories ; Multisystem inflammatory syndrome in children ; Myocarditis ; Patients ; Pediatrics ; Pediatrics General ; Propensity Score ; Public Health Surveillance ; Severe acute respiratory syndrome coronavirus 2 ; Shock - etiology ; Shock - prevention & control ; Software ; Systemic Inflammatory Response Syndrome - complications ; Systemic Inflammatory Response Syndrome - drug therapy ; Systemic Inflammatory Response Syndrome - immunology ; Systemic Inflammatory Response Syndrome - mortality ; Treatment Outcome ; Veins & arteries ; Ventricle ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - prevention & control ; Young Adult</subject><ispartof>The New England journal of medicine, 2021-07, Vol.385 (1), p.23-34</ispartof><rights>Copyright © 2021 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2021 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-4430-6760 ; 0000-0002-4071-0280 ; 0000-0002-6957-1624</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2102605$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2102605$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34133855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Mary Beth F</creatorcontrib><creatorcontrib>Murray, Nancy</creatorcontrib><creatorcontrib>Friedman, Kevin</creatorcontrib><creatorcontrib>Young, Cameron C</creatorcontrib><creatorcontrib>Newhams, Margaret M</creatorcontrib><creatorcontrib>Feldstein, Leora R</creatorcontrib><creatorcontrib>Loftis, Laura L</creatorcontrib><creatorcontrib>Tarquinio, Keiko M</creatorcontrib><creatorcontrib>Singh, Aalok R</creatorcontrib><creatorcontrib>Heidemann, Sabrina M</creatorcontrib><creatorcontrib>Soma, Vijaya L</creatorcontrib><creatorcontrib>Riggs, Becky J</creatorcontrib><creatorcontrib>Fitzgerald, Julie C</creatorcontrib><creatorcontrib>Kong, Michele</creatorcontrib><creatorcontrib>Doymaz, Sule</creatorcontrib><creatorcontrib>Giuliano, John S</creatorcontrib><creatorcontrib>Keenaghan, Michael A</creatorcontrib><creatorcontrib>Hume, Janet R</creatorcontrib><creatorcontrib>Hobbs, Charlotte V</creatorcontrib><creatorcontrib>Schuster, Jennifer E</creatorcontrib><creatorcontrib>Clouser, Katharine N</creatorcontrib><creatorcontrib>Hall, Mark W</creatorcontrib><creatorcontrib>Smith, Lincoln 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Adrienne G</creatorcontrib><creatorcontrib>Overcoming COVID-19 Investigators</creatorcontrib><title>Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascular dysfunction and a lower incidence of adjunctive therapy use than IVIG alone.</description><subject>Adolescent</subject><subject>Allergy</subject><subject>Aneurysms</subject><subject>Biological products</subject><subject>Body temperature</subject><subject>Cardiovascular diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood Diseases</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Combined Modality Therapy</subject><subject>Coronary vessels</subject><subject>Coronavirus</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - drug therapy</subject><subject>COVID-19 - immunology</subject><subject>COVID-19 - mortality</subject><subject>Cytokines</subject><subject>Disease control</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fever</subject><subject>Globulins</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Health surveillance</subject><subject>Heart</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Immunology</subject><subject>Immunology 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R</au><au>Loftis, Laura L</au><au>Tarquinio, Keiko M</au><au>Singh, Aalok R</au><au>Heidemann, Sabrina M</au><au>Soma, Vijaya L</au><au>Riggs, Becky J</au><au>Fitzgerald, Julie C</au><au>Kong, Michele</au><au>Doymaz, Sule</au><au>Giuliano, John S</au><au>Keenaghan, Michael A</au><au>Hume, Janet R</au><au>Hobbs, Charlotte V</au><au>Schuster, Jennifer E</au><au>Clouser, Katharine N</au><au>Hall, Mark W</au><au>Smith, Lincoln S</au><au>Horwitz, Steven M</au><au>Schwartz, Stephanie P</au><au>Irby, Katherine</au><au>Bradford, Tamara T</au><au>Maddux, Aline B</au><au>Babbitt, Christopher J</au><au>Rowan, Courtney M</au><au>McLaughlin, Gwenn E</au><au>Yager, Phoebe H</au><au>Maamari, Mia</au><au>Mack, Elizabeth H</au><au>Carroll, Christopher L</au><au>Montgomery, Vicki L</au><au>Halasa, Natasha B</au><au>Cvijanovich, Natalie Z</au><au>Coates, Bria M</au><au>Rose, Charles E</au><au>Newburger, Jane W</au><au>Patel, Manish M</au><au>Randolph, Adrienne G</au><aucorp>Overcoming COVID-19 Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>385</volume><issue>1</issue><spage>23</spage><epage>34</epage><pages>23-34</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascular dysfunction and a lower incidence of adjunctive therapy use than IVIG alone.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>34133855</pmid><doi>10.1056/NEJMoa2102605</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4430-6760</orcidid><orcidid>https://orcid.org/0000-0002-4071-0280</orcidid><orcidid>https://orcid.org/0000-0002-6957-1624</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-07, Vol.385 (1), p.23-34 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_pubmed_primary_34133855 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Allergy Aneurysms Biological products Body temperature Cardiovascular diseases Child Child, Preschool Childhood Diseases Children Cohort Studies Combined Modality Therapy Coronary vessels Coronavirus Coronaviruses COVID-19 COVID-19 - complications COVID-19 - drug therapy COVID-19 - immunology COVID-19 - mortality Cytokines Disease control Drug Therapy, Combination Female Fever Globulins Glucocorticoids Glucocorticoids - therapeutic use Health surveillance Heart Hospitalization Humans Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Immunology Immunology General Immunomodulation Infant Infectious Disease Inflammation Intravenous administration Length of stay Logistic Models Male Medical laboratories Multisystem inflammatory syndrome in children Myocarditis Patients Pediatrics Pediatrics General Propensity Score Public Health Surveillance Severe acute respiratory syndrome coronavirus 2 Shock - etiology Shock - prevention & control Software Systemic Inflammatory Response Syndrome - complications Systemic Inflammatory Response Syndrome - drug therapy Systemic Inflammatory Response Syndrome - immunology Systemic Inflammatory Response Syndrome - mortality Treatment Outcome Veins & arteries Ventricle Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - prevention & control Young Adult |
| title | Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes |
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