Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes

An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascul...

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Veröffentlicht in:	The New England journal of medicine 2021-07, Vol.385 (1), p.23-34
Hauptverfasser:	Son, Mary Beth F, Murray, Nancy, Friedman, Kevin, Young, Cameron C, Newhams, Margaret M, Feldstein, Leora R, Loftis, Laura L, Tarquinio, Keiko M, Singh, Aalok R, Heidemann, Sabrina M, Soma, Vijaya L, Riggs, Becky J, Fitzgerald, Julie C, Kong, Michele, Doymaz, Sule, Giuliano, John S, Keenaghan, Michael A, Hume, Janet R, Hobbs, Charlotte V, Schuster, Jennifer E, Clouser, Katharine N, Hall, Mark W, Smith, Lincoln S, Horwitz, Steven M, Schwartz, Stephanie P, Irby, Katherine, Bradford, Tamara T, Maddux, Aline B, Babbitt, Christopher J, Rowan, Courtney M, McLaughlin, Gwenn E, Yager, Phoebe H, Maamari, Mia, Mack, Elizabeth H, Carroll, Christopher L, Montgomery, Vicki L, Halasa, Natasha B, Cvijanovich, Natalie Z, Coates, Bria M, Rose, Charles E, Newburger, Jane W, Patel, Manish M, Randolph, Adrienne G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergy Aneurysms Biological products Body temperature Cardiovascular diseases Child Child, Preschool Childhood Diseases Children Cohort Studies Combined Modality Therapy Coronary vessels Coronavirus Coronaviruses COVID-19 COVID-19 - complications COVID-19 - drug therapy COVID-19 - immunology COVID-19 - mortality Cytokines Disease control Drug Therapy, Combination Female Fever Globulins Glucocorticoids Glucocorticoids - therapeutic use Health surveillance Heart Hospitalization Humans Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Immunology Immunology General Immunomodulation Infant Infectious Disease Inflammation Intravenous administration Length of stay Logistic Models Male Medical laboratories Multisystem inflammatory syndrome in children Myocarditis Patients Pediatrics Pediatrics General Propensity Score Public Health Surveillance Severe acute respiratory syndrome coronavirus 2 Shock - etiology Shock - prevention & control Software Systemic Inflammatory Response Syndrome - complications Systemic Inflammatory Response Syndrome - drug therapy Systemic Inflammatory Response Syndrome - immunology Systemic Inflammatory Response Syndrome - mortality Treatment Outcome Veins & arteries Ventricle Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - prevention & control Young Adult
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Beschreibung
Zusammenfassung:	An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascular dysfunction and a lower incidence of adjunctive therapy use than IVIG alone.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2102605