Reperfused vs. nonreperfused myocardial infarction: when to use which model

Reperfused vs. nonreperfused myocardial infarction: when to use which model

There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a p...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2021-07, Vol.321 (1), p.H208-H213
Hauptverfasser: Lindsey, Merry L, de Castro Brás, Lisandra E, DeLeon-Pennell, Kristine Y, Frangogiannis, Nikolaos G, Halade, Ganesh V, O'Meara, Caitlin C, Spinale, Francis G, Kassiri, Zamaneh, Kirk, Jonathan A, Kleinbongard, Petra, Ripplinger, Crystal M, Brunt, Keith R
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Animals
Disease Models, Animal
Heart
Heart attacks
Myocardial Infarction
Myocardial Ischemia
Myocardial Reperfusion
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Zusammenfassung:There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.
ISSN:0363-6135
1522-1539
1522-1539
DOI:10.1152/ajpheart.00234.2021