Translational Control of Immune Evasion in Cancer

Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control...

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Veröffentlicht in:Trends in Cancer 2021-07, Vol.7 (7), p.580-582
Hauptverfasser: Suresh, Shruthy, O'Donnell, Kathryn A
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container_title Trends in Cancer
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creator Suresh, Shruthy
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description Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control of immune checkpoints and implications for cancer immunotherapies.
doi_str_mv 10.1016/j.trecan.2021.04.002
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subjects Disease Progression
Eukaryotic Initiation Factors - metabolism
Gene Expression Regulation, Neoplastic - drug effects
Gene Expression Regulation, Neoplastic - immunology
Humans
Immune Checkpoint Inhibitors - pharmacology
Immune Checkpoint Inhibitors - therapeutic use
Immune Checkpoint Proteins - genetics
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - immunology
Protein Biosynthesis - drug effects
Protein Biosynthesis - immunology
Tumor Escape - drug effects
Tumor Escape - genetics
title Translational Control of Immune Evasion in Cancer
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