Translational Control of Immune Evasion in Cancer

Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control...

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Veröffentlicht in:	Trends in Cancer 2021-07, Vol.7 (7), p.580-582
Hauptverfasser:	Suresh, Shruthy, O'Donnell, Kathryn A
Format:	Artikel
Sprache:	eng
Schlagworte:	Disease Progression Eukaryotic Initiation Factors - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - immunology Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immune Checkpoint Proteins - genetics Neoplasms - drug therapy Neoplasms - genetics Neoplasms - immunology Protein Biosynthesis - drug effects Protein Biosynthesis - immunology Tumor Escape - drug effects Tumor Escape - genetics
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Beschreibung
Zusammenfassung:	Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control of immune checkpoints and implications for cancer immunotherapies.
ISSN:	2405-8033 2405-8025
DOI:	10.1016/j.trecan.2021.04.002