Orthodontic space closure in a young female patient with solitary median maxillary central incisor syndrome

A solitary median maxillary incisor can occur as a rare single dental anomaly or a symptom of the early-intrauterine developmental brain disorder of holoprosencephaly. The few published case reports about orthodontic treatment for this disorder have only described space opening for prosthodontic replacement of a central incisor. In contrast, the present patient was treated with extraction of the solitary median maxillary central incisor and orthodontic space closure with subsequent minimally invasive restorations in order to avoid looming esthetic or periodontal sequelae associated with any type of fixed bridgework or implant-borne crowns in the sensitive maxillary anterior area—which is especially indicated in young girls with a hyperdivergent growth pattern. •Solitary median maxillary central incisor syndrome is a rare genetic mutation.•A girl with Class II Division 1 malocclusion and a missing maxillary central incisor was treated.•The solitary incisor was extracted, and the space closed.•Minimally invasive restorative treatment was finished while the patient was young.