Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection

In a rabbit model of methicillin-resistant Staphylococcus aureus prosthetic joint infection (PJI), prophylaxis with AZD6389*-a combination of three monoclonal antibodies targeting alpha-hemolysin, bicomponent cytotoxins (LukSF/LukED/HlgAB/HlgCB), and clumping factor A-resulted in significant reducti...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2021-06, Vol.65 (7), p.e0183220-e0183220, Article 01832
Hauptverfasser:	Mao, Yanjie, Valour, Florent, Nguyen, Nhu T. Q., Doan, Thien M. N., Koelkebeck, Holly, Richardson, Christopher, Cheng, Lily, Sellman, Bret R., Tkaczyk, Christine, Diep, Binh An
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Experimental Therapeutics Life Sciences & Biomedicine Methicillin-Resistant Staphylococcus aureus Microbiology Pharmacology & Pharmacy Prostheses and Implants Rabbits Science & Technology Staphylococcal Infections - drug therapy Staphylococcus aureus Virulence Virulence Factors
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Zusammenfassung:	In a rabbit model of methicillin-resistant Staphylococcus aureus prosthetic joint infection (PJI), prophylaxis with AZD6389*-a combination of three monoclonal antibodies targeting alpha-hemolysin, bicomponent cytotoxins (LukSF/LukED/HlgAB/HlgCB), and clumping factor A-resulted in significant reductions in joint swelling, erythema, intra-articular pus, and bacterial burden in synovial tissues and biofilm-associated prosthetic implants compared with isotype-matched control IgG. Targeting specific staphylococcal virulence factors may thus have potential clinical utility for prevention of PJI.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.01832-20