A pharmacokinetic comparison of controlled-release and standard naproxen tablets
Summary The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high...
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| Veröffentlicht in: | Current medical research and opinion 1988, Vol.11 (1), p.10-15 |
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| container_title | Current medical research and opinion |
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| creator | Ryley, N. J. Lingam, G. |
| description | Summary
The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high pressure liquid chromatography. The controlled-release formulation produced a significantly (p |
| doi_str_mv | 10.1185/03007998809111125 |
| format | Article |
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The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high pressure liquid chromatography. The controlled-release formulation produced a significantly (p<0.001) lower and later mean peak naproxen concentration than the conventional-release tablets. However, no differences were observed in either area under the plasma concentration-time curve or elimination half-life. The two formulations were judged, therefore, to be bioequivalent based on the total amount of drug absorbed.</description><identifier>ISSN: 0300-7995</identifier><identifier>EISSN: 1473-4877</identifier><identifier>DOI: 10.1185/03007998809111125</identifier><identifier>PMID: 3383611</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adolescent ; Adult ; biological availability ; Delayed-Action Preparations ; Humans ; Naproxen ; Naproxen - administration & dosage ; Naproxen - pharmacokinetics ; Random Allocation ; Tablets</subject><ispartof>Current medical research and opinion, 1988, Vol.11 (1), p.10-15</ispartof><rights>1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-511a287cf6906b1870bc8187249a787ff8dae5966f33454851f43d1c5e7736953</citedby><cites>FETCH-LOGICAL-c401t-511a287cf6906b1870bc8187249a787ff8dae5966f33454851f43d1c5e7736953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1185/03007998809111125$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1185/03007998809111125$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3383611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryley, N. J.</creatorcontrib><creatorcontrib>Lingam, G.</creatorcontrib><title>A pharmacokinetic comparison of controlled-release and standard naproxen tablets</title><title>Current medical research and opinion</title><addtitle>Curr Med Res Opin</addtitle><description>Summary
The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high pressure liquid chromatography. The controlled-release formulation produced a significantly (p<0.001) lower and later mean peak naproxen concentration than the conventional-release tablets. However, no differences were observed in either area under the plasma concentration-time curve or elimination half-life. The two formulations were judged, therefore, to be bioequivalent based on the total amount of drug absorbed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>biological availability</subject><subject>Delayed-Action Preparations</subject><subject>Humans</subject><subject>Naproxen</subject><subject>Naproxen - administration & dosage</subject><subject>Naproxen - pharmacokinetics</subject><subject>Random Allocation</subject><subject>Tablets</subject><issn>0300-7995</issn><issn>1473-4877</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9rFDEUx4ModVv9AzwIc_I2NW8ymSTopRR_QUEPeg5vMy_s1EyyJlls_3tTdhFEaA55hO-PFz6MvQJ-CaDlWy44V8ZozQ20M8gnbAOjEv2olXrKNg963wzyOTsv5ZZzGLQxZ-xMCC0mgA37dtXtd5hXdOnnEqkurnNp3WNeSopd8u0Va04h0NxnCoSFOoxzV2q7Mc9dxH1OdxS7ittAtbxgzzyGQi9P84L9-Pjh-_Xn_ubrpy_XVze9GznUXgLgoJXzk-HTFrTiW6fbGEaDSivv9YwkzTR5IUY5agl-FDM4SUqJyUhxwd4ce9v6Xwcq1a5LcRQCRkqHYpUeFIxSNyMcjS6nUjJ5u8_LivneArcPFO1_FFvm9an8sF1p_ps4YWv6-6O-RJ8avN8ph9lWvA8p-4zRLcWKx-rf_RPfEYa6c5jJ3qZDjo3bI5_7A9Pvkac</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Ryley, N. J.</creator><creator>Lingam, G.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>A pharmacokinetic comparison of controlled-release and standard naproxen tablets</title><author>Ryley, N. J. ; Lingam, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-511a287cf6906b1870bc8187249a787ff8dae5966f33454851f43d1c5e7736953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>biological availability</topic><topic>Delayed-Action Preparations</topic><topic>Humans</topic><topic>Naproxen</topic><topic>Naproxen - administration & dosage</topic><topic>Naproxen - pharmacokinetics</topic><topic>Random Allocation</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryley, N. J.</creatorcontrib><creatorcontrib>Lingam, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current medical research and opinion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryley, N. J.</au><au>Lingam, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pharmacokinetic comparison of controlled-release and standard naproxen tablets</atitle><jtitle>Current medical research and opinion</jtitle><addtitle>Curr Med Res Opin</addtitle><date>1988</date><risdate>1988</risdate><volume>11</volume><issue>1</issue><spage>10</spage><epage>15</epage><pages>10-15</pages><issn>0300-7995</issn><eissn>1473-4877</eissn><abstract>Summary
The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high pressure liquid chromatography. The controlled-release formulation produced a significantly (p<0.001) lower and later mean peak naproxen concentration than the conventional-release tablets. However, no differences were observed in either area under the plasma concentration-time curve or elimination half-life. The two formulations were judged, therefore, to be bioequivalent based on the total amount of drug absorbed.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>3383611</pmid><doi>10.1185/03007998809111125</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-7995 |
| ispartof | Current medical research and opinion, 1988, Vol.11 (1), p.10-15 |
| issn | 0300-7995 1473-4877 |
| language | eng |
| recordid | cdi_pubmed_primary_3383611 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adolescent Adult biological availability Delayed-Action Preparations Humans Naproxen Naproxen - administration & dosage Naproxen - pharmacokinetics Random Allocation Tablets |
| title | A pharmacokinetic comparison of controlled-release and standard naproxen tablets |
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