A pharmacokinetic comparison of controlled-release and standard naproxen tablets

A pharmacokinetic comparison of controlled-release and standard naproxen tablets

Summary The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high...

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Veröffentlicht in:Current medical research and opinion 1988, Vol.11 (1), p.10-15
Hauptverfasser: Ryley, N. J., Lingam, G.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
biological availability
Delayed-Action Preparations
Humans
Naproxen
Naproxen - administration & dosage
Naproxen - pharmacokinetics
Random Allocation
Tablets
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Zusammenfassung:Summary The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high pressure liquid chromatography. The controlled-release formulation produced a significantly (p
ISSN:0300-7995
1473-4877
DOI:10.1185/03007998809111125